PPIRE13707
Target Protein Information
| Protein_Name | T cell receptor alpha variable 27/T cell receptor beta variable 19 |
|---|---|
| Protein_Sequence | MVLKFSVSILWIQLAWVSTQLLEQSPQFLSIQEGENLTVYCNSSSVFSSLQWYRQEPGEGPVLLVTVVTGGEVKKLKRLTFQFGDARKDSSLHITAAQTGDTGLYLCAG/MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSI |
| Organism_Source | Homo sapiens |
| Functional_Classification | T-cell receptor |
| Cellular_Localization | Plasma membrane |
| Gene_Names | TRAV27/TRBV19 |
| UniProt_ID | A0A087WT01/A0A075B6N1 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | M1-L3W |
|---|---|
| Peptide_Sequence | GIWGFVFTL |
| Peptide_Length | 9 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)NCC(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1039.24 |
|---|---|
| Aliphatic_Index | 118.88889 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 3.22222 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 12 |
| Topological_Polar_Surface_Area | 332.14000 |
| X_logP_energy | 0.87790 |
Interaction Information
| Affinity | KD=600 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | 5HHQ |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Molecular basis for universal HLA-A*0201-restricted CD8+ T-cell immunity against influenza viruses. |
| Release_Year | 2016 |
| PMID | 27036003 |
| DOI | 10.1073/pnas.1603106113 |