PPIRE13725

Target Protein Information
Protein_Name Neuropeptide Y receptor type 2
Protein_Sequence MGPVGAKADENQTVEEMKVEKYHPRQTTPRVIALDRHRCIVYHLESKISKRISFLIIGLAWGISALLASPLAIFREYSLIEIIPDFEIVVCTEKWPGEEKNIYGTIYSLSSLLILYVFPLGIISFSYTRIWSKLKNHVSPGAASDHYHQRRQKTTKMLVCVVVVFAVSWLPLHAFQLAVDIDNQVLDLKEYKLIFTVFHIIAMCSTFANPLLYGWMNSNYRKAFLAAFRCEQRLDAIHSEVSVTFKSKKNLEVKKNHGPNDSFSEATNV
Organism_Source Canis lupus familiaris
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names NPY2R
UniProt_ID A0A8C0SG18
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name NPY-(13-36)
Peptide_Sequence APAEDMARYYSALRHYINLITRQRY
Peptide_Length 25
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3072.49
Aliphatic_Index 78.40000
Aromaticity 0.16000
Average_Rotatable_Bonds 3.88000
Charge_at_pH_7 2.08770
Isoelectric_Point 9.66482
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 48
Topological_Polar_Surface_Area 1311.37000
X_logP_energy -10.77762
Interaction Information
Affinity Ki=0.82 nM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX.
Release_Year 1996
PMID None
DOI 10.1152/ajpgi.1996.271.G36