PPIRE13811

Target Protein Information
Protein_Name Transcriptional activator VP30
Protein_Sequence MEASYERGRPRAARQHSRDGHDHHVRARSSSRENYRGEYRQSRSASQVRVPTVFHKKRVEPLTVPPAPKDICPTLKKGFLCDSSFCKKDHQLESLTDRELLLLIARKTCGSVEQQLNITAPKDSRLANPTADDFQQEEGPKITLLTLIKTAEHWARQDIRTIEDSKLRALLTLCAVMTRKFSKSQLSLLCETHLRREGLGQDQAEPVLEVYQRLHSDKGGSFEAALWQQWDRQSLIMFITAFLNIALQLPCESSAVVVSGLRTLVPQSDNEEASTNPGTCSWSDEGTP
Organism_Source Zaire ebolavirus (strain Mayinga-76)
Functional_Classification viral transcription regulators
Cellular_Localization Cytoplasm
Gene_Names VP30
UniProt_ID Q05323
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name RBBP6 peptide(549-573)
Peptide_Sequence SLPATPVFVPVPPPPLYPPPPHTLP
Peptide_Length 25
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)[C@@H](C)O)C(C)C)C(C)C)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2628.15
Aliphatic_Index 85.60000
Aromaticity 0.08000
Average_Rotatable_Bonds 2.20000
Charge_at_pH_7 0.08804
Isoelectric_Point 7.54235
Number_of_Hydrogen_Bond_Acceptors 31
Number_of_Hydrogen_Bond_Donors 19
Topological_Polar_Surface_Area 765.84000
X_logP_energy -1.85520
Interaction Information
Affinity KD=18.11 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Protein Interaction Mapping Identifies RBBP6 as a Negative Regulator of Ebola Virus Replication.
Release_Year 2018
PMID 30550789
DOI 10.1016/j.cell.2018.08.044