PPIRE13813

Target Protein Information
Protein_Name T cell receptor alpha variable 5/T cell receptor beta variable 19
Protein_Sequence MKTFAGFSFLFLWLQLDCMSRGEDVEQSLFLSVREGDSSVINCTYTDSSSTYLYWYKQEPGAGLQLLTYIFSNMDMKQDQRLTVLLNKKDKHLSLRIADTQTGDSAIYFCAES/MSNQVLCCVVLCLLGANTVDGGITQSPKYLFRKEGQNVTLSCEQNLNHDAMYWYRQDPGQGLRLIYYSQIVNDFQKGDIAEGYSVSREKKESFPLTVTSAQKNPTAFYLCASSI
Organism_Source Homo sapiens
Functional_Classification T-cell receptor
Cellular_Localization Plasma membrane
Gene_Names TRAV5/TRBV19
UniProt_ID A0A0B4J249/A0A075B6N1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name KF11
Peptide_Sequence KAFSPEVIPMF
Peptide_Length 11
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCCCN)C(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCSC)C(=O)N[C@@H](Cc1ccccc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1265.53
Aliphatic_Index 70.90909
Aromaticity 0.18182
Average_Rotatable_Bonds 3.36364
Charge_at_pH_7 -0.00054
Isoelectric_Point 6.40880
Number_of_Hydrogen_Bond_Acceptors 16
Number_of_Hydrogen_Bond_Donors 13
Topological_Polar_Surface_Area 420.29000
X_logP_energy -0.79470
Interaction Information
Affinity KD=5.2 uM
Affinity_Assay Surface plasmon resonance
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Structural features underlying T-cell receptor sensitivity to concealed MHC class I micropolymorphisms.
Release_Year 2012
PMID 23161907
DOI 10.1073/pnas.1207896109