PPIRE13819

Target Protein Information
Protein_Name Somatostatin receptor type 2
Protein_Sequence MEMSSEQLNGSQVWVSSPFDLNGSLGPSNGSNQTEPYYDMTSNAVLTFIYFVVCVVGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMINVAVWCVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYAFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSVAISPTPALKGMFDFVVILTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTEDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
Organism_Source Mus musculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names Sstr2
UniProt_ID P30875
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Octreotide
Peptide_Sequence fCFwKTCX
Peptide_Length 8
Peptide_SMILES C[C@@H](O)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@@H](N)Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)NCC(=O)O
Chemical_Modification X8=threoninol
Cyclization_Method Side chain-side chain cyclization; C2<->C7; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification threoninol
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 991.19
Aliphatic_Index 0.00000
Aromaticity 0.37500
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 0.87374
Isoelectric_Point 8.22969
Number_of_Hydrogen_Bond_Acceptors 13
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 329.06000
X_logP_energy -0.99790
Interaction Information
Affinity IC50=3 nM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Isolation, functional characterization, and transcriptome of Mastomys ileal enterochromaffin cells.
Release_Year 2006
PMID 16455786
DOI 10.1152/ajpgi.00552.2005