PPIRE13840

Target Protein Information
Protein_Name NBAS subunit of NRZ tethering complex
Protein_Sequence MAGDIILEDEEENILYDLLVNTEWPPETDTQLRGLKEHNSSLVAKAVTGPFRFFLHYLCPSSSTLPPGLVRLATKQVNWQLVLASNGKLLAVVQDQCVEIRSARDDFGSIIGKCQVPKDPNPHWRRVAWSHDCALLAYADSTGTVRVFDLMGSELFIIPPAMSFPGDFSYAAAGLMFLEYTGSAQWSAELLVITYSGQLKSYLVSVGTNQGFQENHTFSFSAHYSNGITTAIYHPGHRLLLVGGCESGDSDVSRASQCGITAWRVLSGLPHYKQVTSYEDDISSSQRRGFFKMPSFRLFSRHNGEQDGVFRMSLSPDGTILAVIHFSGSLSLWDIPSFKLRGSWKQEEQPGFDEINPEWKTSLEKRKKIKDKEQYQSLLDVSWWSETALILARCSGALTVSSVRTLKNLLGKSCEWFEPSPRVTSAHDGGFLSLECEVKLAHKRSRLESSVKGEEDDGDDDSDSDEEASAKARYFGYVKQGLYYVTEMERFAPPRKRPRTVIKNYRLVSLRSTTPEELYQRKIDNEEYGEALSLAQAYGLDSDLVYQRQWRKSTVSIASIQDYLSKIKKRSWVLHECVERVPENVDAAKELLQYGLKGTDLEALIAIGAREDQGRFILSGDLDMDDAPYEDFLSMEEELEQRKERESKKRQELLKKVDFSKLTLEQKELCRSRLKLLCYLDRLATYEEILGGPHAAEQRFDGEFFKKFRNQNIVLSARTYARESNVQALDILFTYHGAELLQHRLAILCNFPETTSPHEYSDLLPKAGVDKEGNLVLIPWEESRHRDLDWCEVLECREVVEPKPMDDCQFLYEEQPELERFRSADPFITLLTEWYLTRAQDIESHSRQVDCSLSLVRLGKEQNIPGLERLCDDLVTMETLVYETSCDLSVTLKELQQLRDIDKLRLLMKNSSEDRYVRNCFQWMVPFLHRCEGQRVGSASSLLREYLVTLAKDDLTLPLKLFQHSKPDCHPKIIGDSDQLMTVALKCIYSCERDDQLALCYDVLECLPQRGYGPETDTTKALHDQVDTLEKHLSVAEVLEKHGLQKPISFVRNSQNSKEEAHQLMVRLTRHTGRKNPPVSETVWRSLLQDLLDMQQNVYTCLEPETCHQVFVESLLCSSREENVRLAGQLMHCSGVSEDTPVSVSLRGKAHARVSYSRSVELVLAAAREYFNSSATLSDPCMSLARSCLQLITDCPPLVQEELDLITALSRLEQFGVKILPLQVRLRTDRLSLIKECISQCPTAYRQSLLLLSLARLLRVAGDDEAKRKGQVLTLLAEQALLCQDFKASYIHCQELMAAGYSEGWDVCAQLGQCETFTQLSGRQELMAFSLTHCPPSRIQTLLAASSSLQTQVLYQAVNYKIDPSQARRTGSELFEIKVLDDENVTEIPTKLYSVGAAVPGSINPTDLLHRTTARTIEVLTNTTMSTKAVLTTVIDSHWWRESLSLLRPLHGPAVDRNRAGAANQNADLEKQGCSPFYEELFDDPYVNTSEDVYSSYHYNPQEDFAEVLLRTGKLAETNSEGQNLFPATEVLLQLASDAFPKDMTLALAYLLALPQVLDANTCFEKQPPSALSLHLAAYYYSLQIYSRLAPCFKDKCSPLYRADPRALIRLVTKHVTDHAGCDWPDEDLEALIGQLRLYSERLTDFTQAQVLQGLGRGVDVQRFSSDNQYKKETILGLAETLDENVYSISRSLAHRYSIPLWEVHMTHLEFLFTDSGLSTKDIEGRTEALGLFETLKTDPESFYMHMTKYVYPSIAGTDQLRLLFYFTLLENCGCANYFSQTAMKPDTHLKLLKKLKAVAVGLDYKKMTEENSDPLKALEPILTSQNVLSISKLASRIPQKGGEALTSSAVHSTWLHKLFWEGDQHVLKKAPQTDQDFLHAYDTCAKYFDRLLPVDFVNFLDAITFSPEAANKLSVGTRLEITKRAQKALKSISDKTKKKGNDDRSENSAFNFDTALTHVQQSLTHLETLSHSFLLSLKTSQEELLQKYSRIYDLSRSEQSKVHHLAVTMATDGQPLERIEQLLSVAVGTSDLSPKSVVQDAVERIISALSGDKDVLKDYADPLKVLEGIVAVVHTNVQSGGNIVTSEDMLEWLRPFCGDDTKPVRPRIEVLQILEHSFNLSDQDIHLLVYFRSQAILKACWPNRKCEMEDVENEKKRNSLFLELLESSSKWEEFQHLMLLLQAWPPVTDKSRLETDQNPWVCLTSTLLVHSSSVSQINIGNEVLSMCRSLYLTKHKLNPQGIGNISSLLLNAGLKLPALKLMTESKDEHLLKLTQDQIRNITEVTEEVCDTELLSLLLNAGMLISCVDTAVYPSLVSHMLAQGDWDVEKAAYDLQQAGHSAQAGSLLLSYRGSHPGQFTFNSALAVIRKWL
Organism_Source Danio rerio
Functional_Classification Bcl-2 family proteins
Cellular_Localization Mitochondrion
Gene_Names nbas
UniProt_ID Q5TYW4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name zBad
Peptide_Sequence ALWAAKKYGQQLRRMSDEFDKGQMKR
Peptide_Length 26
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3142.65
Aliphatic_Index 41.53846
Aromaticity 0.11538
Average_Rotatable_Bonds 4.30769
Charge_at_pH_7 3.99861
Isoelectric_Point 10.84124
Number_of_Hydrogen_Bond_Acceptors 44
Number_of_Hydrogen_Bond_Donors 49
Topological_Polar_Surface_Area 1378.02000
X_logP_energy -12.73699
Interaction Information
Affinity KD=343 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 6FBX
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title A structural investigation of NRZ mediated apoptosis regulation in zebrafish.
Release_Year 2018
PMID 30237469
DOI 10.1038/s41419-018-0992-0