PPIRE13853

Target Protein Information
Protein_Name NBAS subunit of NRZ tethering complex
Protein_Sequence MAGDIILEDEEENILYDLLVNTEWPPETDTQLRGLKEHNSSLVAKAVTGPFRFFLHYLCPSSSTLPPGLVRLATKQVNWQLVLASNGKLLAVVQDQCVEIRSARDDFGSIIGKCQVPKDPNPHWRRVAWSHDCALLAYADSTGTVRVFDLMGSELFIIPPAMSFPGDFSYAAAGLMFLEYTGSAQWSAELLVITYSGQLKSYLVSVGTNQGFQENHTFSFSAHYSNGITTAIYHPGHRLLLVGGCESGDSDVSRASQCGITAWRVLSGLPHYKQVTSYEDDISSSQRRGFFKMPSFRLFSRHNGEQDGVFRMSLSPDGTILAVIHFSGSLSLWDIPSFKLRGSWKQEEQPGFDEINPEWKTSLEKRKKIKDKEQYQSLLDVSWWSETALILARCSGALTVSSVRTLKNLLGKSCEWFEPSPRVTSAHDGGFLSLECEVKLAHKRSRLESSVKGEEDDGDDDSDSDEEASAKARYFGYVKQGLYYVTEMERFAPPRKRPRTVIKNYRLVSLRSTTPEELYQRKIDNEEYGEALSLAQAYGLDSDLVYQRQWRKSTVSIASIQDYLSKIKKRSWVLHECVERVPENVDAAKELLQYGLKGTDLEALIAIGAREDQGRFILSGDLDMDDAPYEDFLSMEEELEQRKERESKKRQELLKKVDFSKLTLEQKELCRSRLKLLCYLDRLATYEEILGGPHAAEQRFDGEFFKKFRNQNIVLSARTYARESNVQALDILFTYHGAELLQHRLAILCNFPETTSPHEYSDLLPKAGVDKEGNLVLIPWEESRHRDLDWCEVLECREVVEPKPMDDCQFLYEEQPELERFRSADPFITLLTEWYLTRAQDIESHSRQVDCSLSLVRLGKEQNIPGLERLCDDLVTMETLVYETSCDLSVTLKELQQLRDIDKLRLLMKNSSEDRYVRNCFQWMVPFLHRCEGQRVGSASSLLREYLVTLAKDDLTLPLKLFQHSKPDCHPKIIGDSDQLMTVALKCIYSCERDDQLALCYDVLECLPQRGYGPETDTTKALHDQVDTLEKHLSVAEVLEKHGLQKPISFVRNSQNSKEEAHQLMVRLTRHTGRKNPPVSETVWRSLLQDLLDMQQNVYTCLEPETCHQVFVESLLCSSREENVRLAGQLMHCSGVSEDTPVSVSLRGKAHARVSYSRSVELVLAAAREYFNSSATLSDPCMSLARSCLQLITDCPPLVQEELDLITALSRLEQFGVKILPLQVRLRTDRLSLIKECISQCPTAYRQSLLLLSLARLLRVAGDDEAKRKGQVLTLLAEQALLCQDFKASYIHCQELMAAGYSEGWDVCAQLGQCETFTQLSGRQELMAFSLTHCPPSRIQTLLAASSSLQTQVLYQAVNYKIDPSQARRTGSELFEIKVLDDENVTEIPTKLYSVGAAVPGSINPTDLLHRTTARTIEVLTNTTMSTKAVLTTVIDSHWWRESLSLLRPLHGPAVDRNRAGAANQNADLEKQGCSPFYEELFDDPYVNTSEDVYSSYHYNPQEDFAEVLLRTGKLAETNSEGQNLFPATEVLLQLASDAFPKDMTLALAYLLALPQVLDANTCFEKQPPSALSLHLAAYYYSLQIYSRLAPCFKDKCSPLYRADPRALIRLVTKHVTDHAGCDWPDEDLEALIGQLRLYSERLTDFTQAQVLQGLGRGVDVQRFSSDNQYKKETILGLAETLDENVYSISRSLAHRYSIPLWEVHMTHLEFLFTDSGLSTKDIEGRTEALGLFETLKTDPESFYMHMTKYVYPSIAGTDQLRLLFYFTLLENCGCANYFSQTAMKPDTHLKLLKKLKAVAVGLDYKKMTEENSDPLKALEPILTSQNVLSISKLASRIPQKGGEALTSSAVHSTWLHKLFWEGDQHVLKKAPQTDQDFLHAYDTCAKYFDRLLPVDFVNFLDAITFSPEAANKLSVGTRLEITKRAQKALKSISDKTKKKGNDDRSENSAFNFDTALTHVQQSLTHLETLSHSFLLSLKTSQEELLQKYSRIYDLSRSEQSKVHHLAVTMATDGQPLERIEQLLSVAVGTSDLSPKSVVQDAVERIISALSGDKDVLKDYADPLKVLEGIVAVVHTNVQSGGNIVTSEDMLEWLRPFCGDDTKPVRPRIEVLQILEHSFNLSDQDIHLLVYFRSQAILKACWPNRKCEMEDVENEKKRNSLFLELLESSSKWEEFQHLMLLLQAWPPVTDKSRLETDQNPWVCLTSTLLVHSSSVSQINIGNEVLSMCRSLYLTKHKLNPQGIGNISSLLLNAGLKLPALKLMTESKDEHLLKLTQDQIRNITEVTEEVCDTELLSLLLNAGMLISCVDTAVYPSLVSHMLAQGDWDVEKAAYDLQQAGHSAQAGSLLLSYRGSHPGQFTFNSALAVIRKWL
Organism_Source Danio rerio
Functional_Classification Bcl-2 family proteins
Cellular_Localization Mitochondrion
Gene_Names nbas
UniProt_ID Q5TYW4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name zBcl-wav
Peptide_Sequence LCPAPSRASAALRHAGDELLIRFPIF
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](Cc1ccccc1)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2822.32
Aliphatic_Index 109.23077
Aromaticity 0.07692
Average_Rotatable_Bonds 3.30769
Charge_at_pH_7 1.02913
Isoelectric_Point 8.55733
Number_of_Hydrogen_Bond_Acceptors 36
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1093.89000
X_logP_energy -8.46069
Interaction Information
Affinity KD=3570 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title A structural investigation of NRZ mediated apoptosis regulation in zebrafish.
Release_Year 2018
PMID 30237469
DOI 10.1038/s41419-018-0992-0