PPIRE13855

Target Protein Information
Protein_Name NBAS subunit of NRZ tethering complex
Protein_Sequence MAGDIILEDEEENILYDLLVNTEWPPETDTQLRGLKEHNSSLVAKAVTGPFRFFLHYLCPSSSTLPPGLVRLATKQVNWQLVLASNGKLLAVVQDQCVEIRSARDDFGSIIGKCQVPKDPNPHWRRVAWSHDCALLAYADSTGTVRVFDLMGSELFIIPPAMSFPGDFSYAAAGLMFLEYTGSAQWSAELLVITYSGQLKSYLVSVGTNQGFQENHTFSFSAHYSNGITTAIYHPGHRLLLVGGCESGDSDVSRASQCGITAWRVLSGLPHYKQVTSYEDDISSSQRRGFFKMPSFRLFSRHNGEQDGVFRMSLSPDGTILAVIHFSGSLSLWDIPSFKLRGSWKQEEQPGFDEINPEWKTSLEKRKKIKDKEQYQSLLDVSWWSETALILARCSGALTVSSVRTLKNLLGKSCEWFEPSPRVTSAHDGGFLSLECEVKLAHKRSRLESSVKGEEDDGDDDSDSDEEASAKARYFGYVKQGLYYVTEMERFAPPRKRPRTVIKNYRLVSLRSTTPEELYQRKIDNEEYGEALSLAQAYGLDSDLVYQRQWRKSTVSIASIQDYLSKIKKRSWVLHECVERVPENVDAAKELLQYGLKGTDLEALIAIGAREDQGRFILSGDLDMDDAPYEDFLSMEEELEQRKERESKKRQELLKKVDFSKLTLEQKELCRSRLKLLCYLDRLATYEEILGGPHAAEQRFDGEFFKKFRNQNIVLSARTYARESNVQALDILFTYHGAELLQHRLAILCNFPETTSPHEYSDLLPKAGVDKEGNLVLIPWEESRHRDLDWCEVLECREVVEPKPMDDCQFLYEEQPELERFRSADPFITLLTEWYLTRAQDIESHSRQVDCSLSLVRLGKEQNIPGLERLCDDLVTMETLVYETSCDLSVTLKELQQLRDIDKLRLLMKNSSEDRYVRNCFQWMVPFLHRCEGQRVGSASSLLREYLVTLAKDDLTLPLKLFQHSKPDCHPKIIGDSDQLMTVALKCIYSCERDDQLALCYDVLECLPQRGYGPETDTTKALHDQVDTLEKHLSVAEVLEKHGLQKPISFVRNSQNSKEEAHQLMVRLTRHTGRKNPPVSETVWRSLLQDLLDMQQNVYTCLEPETCHQVFVESLLCSSREENVRLAGQLMHCSGVSEDTPVSVSLRGKAHARVSYSRSVELVLAAAREYFNSSATLSDPCMSLARSCLQLITDCPPLVQEELDLITALSRLEQFGVKILPLQVRLRTDRLSLIKECISQCPTAYRQSLLLLSLARLLRVAGDDEAKRKGQVLTLLAEQALLCQDFKASYIHCQELMAAGYSEGWDVCAQLGQCETFTQLSGRQELMAFSLTHCPPSRIQTLLAASSSLQTQVLYQAVNYKIDPSQARRTGSELFEIKVLDDENVTEIPTKLYSVGAAVPGSINPTDLLHRTTARTIEVLTNTTMSTKAVLTTVIDSHWWRESLSLLRPLHGPAVDRNRAGAANQNADLEKQGCSPFYEELFDDPYVNTSEDVYSSYHYNPQEDFAEVLLRTGKLAETNSEGQNLFPATEVLLQLASDAFPKDMTLALAYLLALPQVLDANTCFEKQPPSALSLHLAAYYYSLQIYSRLAPCFKDKCSPLYRADPRALIRLVTKHVTDHAGCDWPDEDLEALIGQLRLYSERLTDFTQAQVLQGLGRGVDVQRFSSDNQYKKETILGLAETLDENVYSISRSLAHRYSIPLWEVHMTHLEFLFTDSGLSTKDIEGRTEALGLFETLKTDPESFYMHMTKYVYPSIAGTDQLRLLFYFTLLENCGCANYFSQTAMKPDTHLKLLKKLKAVAVGLDYKKMTEENSDPLKALEPILTSQNVLSISKLASRIPQKGGEALTSSAVHSTWLHKLFWEGDQHVLKKAPQTDQDFLHAYDTCAKYFDRLLPVDFVNFLDAITFSPEAANKLSVGTRLEITKRAQKALKSISDKTKKKGNDDRSENSAFNFDTALTHVQQSLTHLETLSHSFLLSLKTSQEELLQKYSRIYDLSRSEQSKVHHLAVTMATDGQPLERIEQLLSVAVGTSDLSPKSVVQDAVERIISALSGDKDVLKDYADPLKVLEGIVAVVHTNVQSGGNIVTSEDMLEWLRPFCGDDTKPVRPRIEVLQILEHSFNLSDQDIHLLVYFRSQAILKACWPNRKCEMEDVENEKKRNSLFLELLESSSKWEEFQHLMLLLQAWPPVTDKSRLETDQNPWVCLTSTLLVHSSSVSQINIGNEVLSMCRSLYLTKHKLNPQGIGNISSLLLNAGLKLPALKLMTESKDEHLLKLTQDQIRNITEVTEEVCDTELLSLLLNAGMLISCVDTAVYPSLVSHMLAQGDWDVEKAAYDLQQAGHSAQAGSLLLSYRGSHPGQFTFNSALAVIRKWL
Organism_Source Danio rerio
Functional_Classification Bcl-2 family proteins
Cellular_Localization Mitochondrion
Gene_Names nbas
UniProt_ID Q5TYW4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name zBik
Peptide_Sequence NMRVTQTIGRQLAQIGDEMDNKWRQE
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CC(N)=O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3118.49
Aliphatic_Index 60.00000
Aromaticity 0.03846
Average_Rotatable_Bonds 4.23077
Charge_at_pH_7 0.00212
Isoelectric_Point 6.62714
Number_of_Hydrogen_Bond_Acceptors 45
Number_of_Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1466.53000
X_logP_energy -17.00229
Interaction Information
Affinity KD=12 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title A structural investigation of NRZ mediated apoptosis regulation in zebrafish.
Release_Year 2018
PMID 30237469
DOI 10.1038/s41419-018-0992-0