PPIRE13859

Target Protein Information
Protein_Name NBAS subunit of NRZ tethering complex
Protein_Sequence MAGDIILEDEEENILYDLLVNTEWPPETDTQLRGLKEHNSSLVAKAVTGPFRFFLHYLCPSSSTLPPGLVRLATKQVNWQLVLASNGKLLAVVQDQCVEIRSARDDFGSIIGKCQVPKDPNPHWRRVAWSHDCALLAYADSTGTVRVFDLMGSELFIIPPAMSFPGDFSYAAAGLMFLEYTGSAQWSAELLVITYSGQLKSYLVSVGTNQGFQENHTFSFSAHYSNGITTAIYHPGHRLLLVGGCESGDSDVSRASQCGITAWRVLSGLPHYKQVTSYEDDISSSQRRGFFKMPSFRLFSRHNGEQDGVFRMSLSPDGTILAVIHFSGSLSLWDIPSFKLRGSWKQEEQPGFDEINPEWKTSLEKRKKIKDKEQYQSLLDVSWWSETALILARCSGALTVSSVRTLKNLLGKSCEWFEPSPRVTSAHDGGFLSLECEVKLAHKRSRLESSVKGEEDDGDDDSDSDEEASAKARYFGYVKQGLYYVTEMERFAPPRKRPRTVIKNYRLVSLRSTTPEELYQRKIDNEEYGEALSLAQAYGLDSDLVYQRQWRKSTVSIASIQDYLSKIKKRSWVLHECVERVPENVDAAKELLQYGLKGTDLEALIAIGAREDQGRFILSGDLDMDDAPYEDFLSMEEELEQRKERESKKRQELLKKVDFSKLTLEQKELCRSRLKLLCYLDRLATYEEILGGPHAAEQRFDGEFFKKFRNQNIVLSARTYARESNVQALDILFTYHGAELLQHRLAILCNFPETTSPHEYSDLLPKAGVDKEGNLVLIPWEESRHRDLDWCEVLECREVVEPKPMDDCQFLYEEQPELERFRSADPFITLLTEWYLTRAQDIESHSRQVDCSLSLVRLGKEQNIPGLERLCDDLVTMETLVYETSCDLSVTLKELQQLRDIDKLRLLMKNSSEDRYVRNCFQWMVPFLHRCEGQRVGSASSLLREYLVTLAKDDLTLPLKLFQHSKPDCHPKIIGDSDQLMTVALKCIYSCERDDQLALCYDVLECLPQRGYGPETDTTKALHDQVDTLEKHLSVAEVLEKHGLQKPISFVRNSQNSKEEAHQLMVRLTRHTGRKNPPVSETVWRSLLQDLLDMQQNVYTCLEPETCHQVFVESLLCSSREENVRLAGQLMHCSGVSEDTPVSVSLRGKAHARVSYSRSVELVLAAAREYFNSSATLSDPCMSLARSCLQLITDCPPLVQEELDLITALSRLEQFGVKILPLQVRLRTDRLSLIKECISQCPTAYRQSLLLLSLARLLRVAGDDEAKRKGQVLTLLAEQALLCQDFKASYIHCQELMAAGYSEGWDVCAQLGQCETFTQLSGRQELMAFSLTHCPPSRIQTLLAASSSLQTQVLYQAVNYKIDPSQARRTGSELFEIKVLDDENVTEIPTKLYSVGAAVPGSINPTDLLHRTTARTIEVLTNTTMSTKAVLTTVIDSHWWRESLSLLRPLHGPAVDRNRAGAANQNADLEKQGCSPFYEELFDDPYVNTSEDVYSSYHYNPQEDFAEVLLRTGKLAETNSEGQNLFPATEVLLQLASDAFPKDMTLALAYLLALPQVLDANTCFEKQPPSALSLHLAAYYYSLQIYSRLAPCFKDKCSPLYRADPRALIRLVTKHVTDHAGCDWPDEDLEALIGQLRLYSERLTDFTQAQVLQGLGRGVDVQRFSSDNQYKKETILGLAETLDENVYSISRSLAHRYSIPLWEVHMTHLEFLFTDSGLSTKDIEGRTEALGLFETLKTDPESFYMHMTKYVYPSIAGTDQLRLLFYFTLLENCGCANYFSQTAMKPDTHLKLLKKLKAVAVGLDYKKMTEENSDPLKALEPILTSQNVLSISKLASRIPQKGGEALTSSAVHSTWLHKLFWEGDQHVLKKAPQTDQDFLHAYDTCAKYFDRLLPVDFVNFLDAITFSPEAANKLSVGTRLEITKRAQKALKSISDKTKKKGNDDRSENSAFNFDTALTHVQQSLTHLETLSHSFLLSLKTSQEELLQKYSRIYDLSRSEQSKVHHLAVTMATDGQPLERIEQLLSVAVGTSDLSPKSVVQDAVERIISALSGDKDVLKDYADPLKVLEGIVAVVHTNVQSGGNIVTSEDMLEWLRPFCGDDTKPVRPRIEVLQILEHSFNLSDQDIHLLVYFRSQAILKACWPNRKCEMEDVENEKKRNSLFLELLESSSKWEEFQHLMLLLQAWPPVTDKSRLETDQNPWVCLTSTLLVHSSSVSQINIGNEVLSMCRSLYLTKHKLNPQGIGNISSLLLNAGLKLPALKLMTESKDEHLLKLTQDQIRNITEVTEEVCDTELLSLLLNAGMLISCVDTAVYPSLVSHMLAQGDWDVEKAAYDLQQAGHSAQAGSLLLSYRGSHPGQFTFNSALAVIRKWL
Organism_Source Danio rerio
Functional_Classification Bcl-2 family proteins
Cellular_Localization Mitochondrion
Gene_Names nbas
UniProt_ID Q5TYW4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name zBax
Peptide_Sequence ELCDPSHKRLAQCLQQIGDELDGNAQLQ
Peptide_Length 28
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CO)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CCC(=O)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3123.46
Aliphatic_Index 90.71429
Aromaticity 0.00000
Average_Rotatable_Bonds 3.85714
Charge_at_pH_7 -3.03046
Isoelectric_Point 4.22729
Number_of_Hydrogen_Bond_Acceptors 46
Number_of_Hydrogen_Bond_Donors 47
Topological_Polar_Surface_Area 1422.10000
X_logP_energy -16.86013
Interaction Information
Affinity KD=688 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title A structural investigation of NRZ mediated apoptosis regulation in zebrafish.
Release_Year 2018
PMID 30237469
DOI 10.1038/s41419-018-0992-0