PPIRE13881
Target Protein Information
| Protein_Name | Histone-binding protein RBBP7 |
|---|---|
| Protein_Sequence | MASKEMFEDTVEERVINEEYKIWKKNTPFLYDLVMTHALQWPSLTVQWLPEVTKPEGKDYALHWLVLGTHTSDEQNHLVVARVHIPNDDAQFDASHCDSDKGEFGGFGSVTGKIECEIKINHEGEVNRARYMPQNPHIIATKTPSSDVLVFDYTKHPAKPDPSGECNPDLRLRGHQKEGYGLSWNSNLSGHLLSASDDHTVCLWDINAGPKEGKIVDAKAIFTGHSAVVEDVAWHLLHESLFGSVADDQKLMIWDTRSNTTSKPSHLVDAHTAEVNCLSFNPYSEFILATGSADKTVALWDLRNLKLKLHTFESHKDEIFQVHWSPHNETILASSGTDRRLNVWDLSKIGEEQSAEDAEDGPPELLFIHGGHTAKISDFSWNPNEPWVICSVSEDNIMQIWQMAENIYNDEESDVTTSELEGQGS |
| Organism_Source | Homo sapiens |
| Functional_Classification | histone chaperones |
| Cellular_Localization | Nucleus |
| Gene_Names | RBBP7 |
| UniProt_ID | Q16576 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Histone H4 peptide(16-41) |
|---|---|
| Peptide_Sequence | KRHRKVLRDNIQGITKPAIRRLARRG |
| Peptide_Length | 26 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CCCCN)C(C)C)[C@@H](C)CC)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)O)[C@@H](C)CC)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3109.73 |
|---|---|
| Aliphatic_Index | 93.84615 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.26923 |
| Charge_at_pH_7 | 9.08843 |
| Isoelectric_Point | 12.90508 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 42 |
| Number_of_Hydrogen_Bond_Donors | 55 |
| Topological_Polar_Surface_Area | 1465.78000 |
| X_logP_energy | -15.59431 |
Interaction Information
| Affinity | KD=1 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | 3CFV |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structural basis for the recognition of histone H4 by the histone-chaperone RbAp46. |
| Release_Year | 2008 |
| PMID | 18571423 |
| DOI | 10.1016/j.str.2008.05.006 |