PPIRE13889

Target Protein Information
Protein_Name Apoptosis regulator Bcl-2 homolog
Protein_Sequence MASSNMKDETYYIALNMIQNYIIEYNTNKPRKSFVIDSISYDVLKAACKSVIKTNYNEFDIIISRNIDFNVIVTQVLEDKINWGRIITIIAFCAYYSKKVKQDTSPQYYDGIISEAITDAILSKYRSWFIDQDYWNGIRIYKNYSYIFNTASYCIFTASLIIASLAVFKICSFYM
Organism_Source Fowlpox virus (strain NVSL)
Functional_Classification apoptosis regulators
Cellular_Localization Mitochondrion
Gene_Names None
UniProt_ID Q9J5G4
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name HS_Bad
Peptide_Sequence NLWAAQRYGRELRRMSDEFVDSFKKG
Peptide_Length 26
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)CNC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3160.56
Aliphatic_Index 48.84615
Aromaticity 0.15385
Average_Rotatable_Bonds 4.15385
Charge_at_pH_7 2.00097
Isoelectric_Point 10.23217
Number_of_Hydrogen_Bond_Acceptors 43
Number_of_Hydrogen_Bond_Donors 51
Topological_Polar_Surface_Area 1402.32000
X_logP_energy -13.40452
Interaction Information
Affinity KD=653 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural basis of apoptosis inhibition by the fowlpox virus protein FPV039.
Release_Year 2017
PMID 28411240
DOI 10.1074/jbc.M116.768879