PPIRE13890
Target Protein Information
| Protein_Name | Pyruvate kinase |
|---|---|
| Protein_Sequence | MSSFKYKNSAAGASMQSAANITLRQILEPNNVNLRSKKTHIVCTLGPACKSVETLVKLIDAGMDICRFNFSHGSHEDHKEMFNNVLKAQELRPNCLLGMLLDTKGPEIRTGFLKNKEVHLKEGSKLKLVTDYEFLGDETCIACSYKKLPQSVKPGNIILIADGSVSCKVLETHEDHVITEVLNSAVIGERKNMNLPNVKVDLPIISEKDKNDILNFAIPMGCNFIAASFIQSADDVRLIRNLLGPRGRHIKIIPKIENIEGIIHFDKILAESDGIMIARGDLGMEISPEKVFLAQKLMISKCNLQGKPIITATQMLESMTKNPRPTRAEVTDVANAVLDGTDCVMLSGETAGGKFPVEAVTIMSKICLEAEACIDYKLLYQSLVNAIETPISVQEAVARSAVETAESIQASLIIALTETGYTARLIAKYKPSCTILALSASDSTVKCLNVHRGVTCIKVGSFQGTDIVIRNAIEIAKQRNMAKVGDSVIAIHGIKEEVSGGTNLMKVVQIE |
| Organism_Source | Plasmodium falciparum (isolate 3D7) |
| Functional_Classification | kinases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | None |
| UniProt_ID | C6KTA4 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | LZ1 |
|---|---|
| Peptide_Sequence | VKRWKKWWRKWKKWV |
| Peptide_Length | 15 |
| Peptide_SMILES | CC(C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@H](C(=O)O)C(C)C |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 2228.77 |
|---|---|
| Aliphatic_Index | 38.66667 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 4.86667 |
| Charge_at_pH_7 | 7.99621 |
| Isoelectric_Point | 12.58456 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 24 |
| Number_of_Hydrogen_Bond_Donors | 33 |
| Topological_Polar_Surface_Area | 829.59000 |
| X_logP_energy | 1.41804 |
Interaction Information
| Affinity | IC50=3.045 uM |
|---|---|
| Affinity_Assay | in vitro antiplasmodial assay |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | In Vitro and In Vivo Antimalarial Activity of LZ1, a Peptide Derived from Snake Cathelicidin. |
| Release_Year | 2019 |
| PMID | 31262018 |
| DOI | 10.3390/toxins11070379 |