PPIRE13892

Target Protein Information
Protein_Name Apoptosis regulator Bcl-2 homolog
Protein_Sequence MEGEELIYHNIINEILVGYIKYYINDISEHELSPYQQQIKKILTYYDECLNKQVTITFSLTSVQEIKTQFTGVVTELFKDLINWGRICGFIVFSAKMAKYCKDANNHLESTVITTAYNFMKHNLLPWMISHGGQEEFLAFSLHSDMYSVIFNIKYFLSKFCNHMFFRSCVQLLRNCNLI
Organism_Source African swine fever virus (strain Badajoz 1971 Vero-adapted)
Functional_Classification Bcl-2 family
Cellular_Localization Mitochondrion
Gene_Names None
UniProt_ID P42485
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ss_Noxa
Peptide_Sequence PPDPEVECAIQFRRIGDKLNFRQKLL
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H]1CCCN1)C(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3083.60
Aliphatic_Index 90.00000
Aromaticity 0.07692
Average_Rotatable_Bonds 3.96154
Charge_at_pH_7 0.93985
Isoelectric_Point 8.54029
Number_of_Hydrogen_Bond_Acceptors 40
Number_of_Hydrogen_Bond_Donors 44
Topological_Polar_Surface_Area 1275.46000
X_logP_energy -9.95839
Interaction Information
Affinity KD=1575 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis.
Release_Year 2017
PMID 28053104
DOI 10.1128/JVI.02228-16