PPIRE13903

Target Protein Information
Protein_Name Apoptosis regulator Bcl-2 homolog
Protein_Sequence MEGEELIYHNIINEILVGYIKYYINDISEHELSPYQQQIKKILTYYDECLNKQVTITFSLTSVQEIKTQFTGVVTELFKDLINWGRICGFIVFSAKMAKYCKDANNHLESTVITTAYNFMKHNLLPWMISHGGQEEFLAFSLHSDMYSVIFNIKYFLSKFCNHMFFRSCVQLLRNCNLI
Organism_Source African swine fever virus (strain Badajoz 1971 Vero-adapted)
Functional_Classification Bcl-2 family
Cellular_Localization Mitochondrion
Gene_Names None
UniProt_ID P42485
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ssBik
Peptide_Sequence SSEAPHHLAMQLASIADDLELRLLLP
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2841.27
Aliphatic_Index 135.38462
Aromaticity 0.00000
Average_Rotatable_Bonds 3.53846
Charge_at_pH_7 -2.81576
Isoelectric_Point 4.53289
Number_of_Hydrogen_Bond_Acceptors 39
Number_of_Hydrogen_Bond_Donors 38
Topological_Polar_Surface_Area 1145.48000
X_logP_energy -9.15153
Interaction Information
Affinity KD=190 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis.
Release_Year 2017
PMID 28053104
DOI 10.1128/JVI.02228-16