PPIRE13915

Target Protein Information
Protein_Name Guanylate cyclase
Protein_Sequence MVPAEAMPRPGRPSGARLRLLLLLPPLLLLPGSYAGNLTVAVVLPLTNTSYPWSWARVGPAVELALARVKARPDLLPGWTVRTVLGSSESALGVCSDTAAPLAAVDLKWEHSPAVFLGPGCVYAAAPVGRFTAHWRVPLLTAGAPAVGFGAKDEYALTTRAGPSHAKLGDFVAALHRRLGWERQALVLYAYQPGDDQPCFFVVEGLYMRVRDRLNITVDHLEFAEGDRDHYTMLLRTVRRKGRVIYICSSPDTFRALMLLALEAGLSGNDYVFFHLDLFGQSLQGAHGIAPRRPWERGDGQDVSAHQAFRAAKIITYKEPDNPEYLEFLQKLKRLALEQFNFTMEDGLVNTIPASFHDGLLLYIQAVTETLAHGGAVTDGEGITQRMWNRSFQGVTGYLKMDSNGDRETDFSLWDMDPNTGAFRVVLNFNGTSQELMTMSGCKLNWPLGYPPPDVPKCGFDNEDPACNQDHFSTLEVLALVGSLSLLSILIVSFFIYRKMQLEKELASELWRVRWEDLQPSSLERHLRSAGSRLTLSGRGSNYGSLLTTEGQLQIFAKTAYYKGNLVAVKRVNRKRIELTREVLFELKHMRDVQNEHLTRFVGACTDPPNICILTEYCPRGSLQDILENESITLDWMFRYSLTNDIVKGMLFLHNGAICSHGNLKSSNCVVDGRFVLKITDYGLESFRDPEPEQGHTLYAKKLWTAPELLRMASPPARGSQAGDVYSFGIILQEIALRSGAFHVEGLDLSPKEIIERVTRGEQPPFRPSLALQSHLEELGQLMQRCWAEDPQERPPFQQIRLMLRKFNRENSSNILDNLLSRMEQYANNLEELVEERTQAYLEEKRKAEALLYQILPHSVAEQLKRGETVQAEAFDSVTIYFSDIVGFTALSAESTPMQVVTLLNDLYTCFDAVIDNFDVYKVETIGDAYMVVSGLPVRNGRLHAREVARMALALLDAVRSFRIRHRPQEQLRLRIGIHTGPVCAGVVGLKMPRYCLFGDTVNTASRMESNGEALKIHLSSETKAVLEEFGGFELELRGDVEMKGKGKVRTYWLLGERGSSTRG
Organism_Source Bos taurus
Functional_Classification receptor guanylate cyclase
Cellular_Localization Plasma membrane
Gene_Names NPR1
UniProt_ID E1BN71
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Atrial natriuretic peptide(ANP)
Peptide_Sequence SLRSSCFGGMDRIGAQSGLGCNSFRY
Peptide_Length 26
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCSC)NC(=O)CNC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CO)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C23; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2770.11
Aliphatic_Index 48.84615
Aromaticity 0.11538
Average_Rotatable_Bonds 3.53846
Charge_at_pH_7 1.87362
Isoelectric_Point 8.80375
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 47
Topological_Polar_Surface_Area 1221.38000
X_logP_energy -17.75319
Interaction Information
Affinity EC50=35.6 pM
Affinity_Assay ELISA
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Brain and atrial natriuretic peptides bind to common receptors in brain capillary endothelial cells.
Release_Year 1993
PMID 1678581
DOI 10.1152/ajpendo.1991.261.2.e183