PPIRE13924
Target Protein Information
| Protein_Name | cAMP-dependent protein kinase type I-alpha regulatory subunit |
|---|---|
| Protein_Sequence | MASGTTASEEERSLRECELYVQKHNIQALLKDSIVQLCTARPERPMAFLREYFEKLEKEEAKQIQNLQKAGSRADSREDEISPPPPNPVVKGRRRRGAISAEVYTEEDAASYVRKVIPKDYKTMAALAKAIEKNVLFSHLDDNERSDIFDAMFPVSFIAGETVIQQGDEGDNFYVIDQGEMDVYVNNEWATSVGEGGSFGELALIYGTPRAATVKAKTNVKLWGIDRDSYRRILMGSTLRKRKMYEEFLSKVSILESLDKWERLTVADALEPVQFEDGQKIVVQGEPGDEFFIILEGSAAVLQRRSENEEFVEVGRLGPSDYFGEIALLMNRPRAATVVARGPLKCVKLDRPRFERVLGPCSDILKRNIQQYNSFVSLSV |
| Organism_Source | Bos taurus |
| Functional_Classification | kinases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | PRKAR1A |
| UniProt_ID | P00514 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | D-AKAP2 AKB peptide |
|---|---|
| Peptide_Sequence | DEAQEELAWKIAKMIVSDVMQQAQYDQ |
| Peptide_Length | 27 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(N)=O)C(=O)O)C(C)C)C(C)C)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3168.54 |
|---|---|
| Aliphatic_Index | 79.62963 |
| Aromaticity | 0.07407 |
| Average_Rotatable_Bonds | 4.07407 |
| Charge_at_pH_7 | -3.99679 |
| Isoelectric_Point | 3.81507 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 45 |
| Number_of_Hydrogen_Bond_Donors | 44 |
| Topological_Polar_Surface_Area | 1367.46000 |
| X_logP_energy | -11.69220 |
Interaction Information
| Affinity | KD=48 nM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 3IM4 |
| Type | antagonist |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Structure of D-AKAP2:PKA RI complex: insights into AKAP specificity and selectivity. |
| Release_Year | 2010 |
| PMID | 20159461 |
| DOI | 10.1016/j.str.2009.12.012 |