PPIRE13959

Target Protein Information
Protein_Name Minor fimbrium subunit Mfa1
Protein_Sequence MKLNKMFLVGALLSLGFASCSKEGNGPAPDSSSTADTHMSVSMSLPQHNRAGDNDYNPIGEYGGVDKINDLTVYVVGDGKIDVRKLSTADLQVNQGASTTSIVTAPFQVKSGEKTVYAIVNITPKVEAALNAATNAADLKVAYEAAYAAFSDAGSEIATLVNNQDQMIMSGKPVVQTILANVSAANASVQNKVPIIVKRAAIRASMTITQQPVNGAYEIKALRPGNVEVGIATVSDLKWAVAQYEKKYYLQQKDNALSPAASFVPASTNDYNGANGAMKHYDYSQLANRITVHQLNAPYSVTDVPNVAYKYVSETTHADNDYRKGNTTYILVKGKLKPVAAMWADGEQAAYQEGGDLFLGLVTGKFYANEANANAANPASGGAGNPRVVTYKAAAVYYYAWLNPNTLDPTTWTMSPARRNNIYNVNISKFRNIGLSGNPFVPTDPDPNNPDTPDNPDTPDPEDPDTPNPEEPLPVQKTYMVVDVTVTPWTLHNYDIEF
Organism_Source Porphyromonas gingivalis
Functional_Classification adhesins
Cellular_Localization Plasma membrane
Gene_Names mfa1
UniProt_ID P81363
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name BAR
Peptide_Sequence LEAAPKKVQDLLKKANITVKGAFQLFS
Peptide_Length 27
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(C)C)C(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CO)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2958.54
Aliphatic_Index 108.51852
Aromaticity 0.07407
Average_Rotatable_Bonds 3.81481
Charge_at_pH_7 2.99873
Isoelectric_Point 10.62727
Number_of_Hydrogen_Bond_Acceptors 40
Number_of_Hydrogen_Bond_Donors 39
Topological_Polar_Surface_Area 1185.56000
X_logP_energy -8.98780
Interaction Information
Affinity IC50=1.3 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide-modified nanoparticles inhibit formation of Porphyromonas gingivalis biofilms with Streptococcus gordonii.
Release_Year 2017
PMID 28790818
DOI 10.2147/IJN.S139178