PPIRE13979
Target Protein Information
| Protein_Name | Peptidyl-prolyl cis-trans isomerase |
|---|---|
| Protein_Sequence | MKVGQDKVVTIRYTLQVEGEVLDQGELSYLHGHRNLIQGLEEALEGREEGEAFQAHVPAEKAYGPHDPEGVQVVPLSAFPEDAEVVPGAQFYAQDMEGNPMPLTVVAVEGEEVTVDFNHPLAGKDLDFQVEVVKVREATSEELLHVH |
| Organism_Source | Thermus thermophilus |
| Functional_Classification | peptidyl-prolyl cis/trans isomerase |
| Cellular_Localization | Cytoplasm |
| Gene_Names | slyD |
| UniProt_ID | A0A3P4ASJ6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Tat signal peptide |
|---|---|
| Peptide_Sequence | XXXXXXXXXXXXXXXXXXXXXXXXXXX |
| Peptide_Length | 27 |
| Peptide_SMILES | NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1558.42 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 1.96296 |
| Charge_at_pH_7 | -0.00202 |
| Isoelectric_Point | 6.10000 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 28 |
| Number_of_Hydrogen_Bond_Donors | 28 |
| Topological_Polar_Surface_Area | 819.92000 |
| X_logP_energy | -23.94910 |
Interaction Information
| Affinity | KD=0.1 uM |
|---|---|
| Affinity_Assay | fluorescence |
| PDB_ID | 3CGM |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Crystal structure determination and functional characterization of the metallochaperone SlyD from Thermus thermophilus. |
| Release_Year | 2010 |
| PMID | 20230833 |
| DOI | 10.1016/j.jmb.2010.03.014 |