PPIRE14000

Target Protein Information
Protein_Name MOB kinase activator 1A
Protein_Sequence MSFLFSSRSSKTFKPKKNIPEGSHQYELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDFFNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTNIKKPIKCSAPKYIDYLMTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFDSVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLGSKDR
Organism_Source Homo sapiens
Functional_Classification Hippo pathway scaffold
Cellular_Localization Cytoplasm
Gene_Names MOB1A
UniProt_ID Q9H8S9
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Mst2deltaL/MBM
Peptide_Sequence DEEEEDXMKRNATSPQVQRPSFMDYFDK
Peptide_Length 28
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C)[C@@H](C)O
Chemical_Modification X7=phosphothreonine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3350.59
Aliphatic_Index 13.92857
Aromaticity 0.10714
Average_Rotatable_Bonds 4.03571
Charge_at_pH_7 -3.99458
Isoelectric_Point 4.05701
Number_of_Hydrogen_Bond_Acceptors 50
Number_of_Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1515.87000
X_logP_energy -17.33816
Interaction Information
Affinity KD=230 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Release_Year 2015
PMID 26108669
DOI 10.1101/gad.264929.115