PPIRE14103

Target Protein Information
Protein_Name Apoptosis regulator Bcl-2 homolog
Protein_Sequence MEGEELIYHNIINEILVGYIKYYINDISEHELSPYQQQIKKILTYYDECLNKQVTITFSLTSVQEIKTQFTGVVTELFKDLINWGRICGFIVFSAKMAKYCKDANNHLESTVITTAYNFMKHNLLPWMISHGGQEEFLAFSLHSDMYSVIFNIKYFLSKFCNHMFFRSCVQLLRNCNLI
Organism_Source African swine fever virus (strain Badajoz 1971 Vero-adapted)
Functional_Classification Bcl-2 family
Cellular_Localization Mitochondrion
Gene_Names None
UniProt_ID P42485
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name ss_Bax
Peptide_Sequence VPQDASTKKLSECLKRIGDELDSNMELQ
Peptide_Length 28
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)[C@@H](C)O)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3148.55
Aliphatic_Index 83.57143
Aromaticity 0.00000
Average_Rotatable_Bonds 4.00000
Charge_at_pH_7 -2.05821
Isoelectric_Point 4.35508
Number_of_Hydrogen_Bond_Acceptors 48
Number_of_Hydrogen_Bond_Donors 48
Topological_Polar_Surface_Area 1414.18000
X_logP_energy -16.35233
Interaction Information
Affinity KD=26 nM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 5UA4
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Structural Insight into African Swine Fever Virus A179L-Mediated Inhibition of Apoptosis.
Release_Year 2017
PMID 28053104
DOI 10.1128/JVI.02228-16