PPIRE14109

Target Protein Information
Protein_Name Potassium voltage-gated channel subfamily A member 1
Protein_Sequence MTVMSGENADEASTAPGHPQDGSYPRQADHDDHECCERVVINISGLRFETQLKTLAQFPNTLLGNPKKRMRYFDPLRNEYFFDRNRPSFDAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEKFREDEGFIKEEERPLPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCLETLPELKDDKDFTGTIHRIDNTTVIYTSNIFTDPFFIVETLCIIWFSFELVVRFFACPSKTDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEAEEAESHFSSIPDAFWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQLLHVSSPNLASDSDLSRRSSSTISKSEYMEIEEDMNNSIAHYRQANIRTGNCTTADQNCVNKSKLLTDV
Organism_Source Mus musculus
Functional_Classification voltage-gated potassium channels
Cellular_Localization Plasma membrane
Gene_Names Kcna1
UniProt_ID P16388
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name S-AAM hKv3.4
Peptide_Sequence XISSVCVSSYRGRKSGNKPPSKTCLKEE
Peptide_Length 28
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)NCC(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)O)[C@@H](C)O)C(C)C)C(C)C
Chemical_Modification X1=norleucine; C6=S-acetamidomethyl; C24=S-acetamidomethyl
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Acetyl
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2998.42
Aliphatic_Index 48.57143
Aromaticity 0.03571
Average_Rotatable_Bonds 3.64286
Charge_at_pH_7 3.87555
Isoelectric_Point 10.05347
Number_of_Hydrogen_Bond_Acceptors 48
Number_of_Hydrogen_Bond_Donors 50
Topological_Polar_Surface_Area 1338.85000
X_logP_energy -19.41126
Interaction Information
Affinity KD=175 uM
Affinity_Assay electrophysiology; whole-cell patch clamp
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Studies on the blocking action of human Kv3.4 inactivation peptide variants in the mouse cloned Kv1.1 K+ channel.
Release_Year 1996
PMID 8910203
DOI 10.1113/jphysiol.1996.sp021672