PPIRE14193
Target Protein Information
| Protein_Name | Acid-sensing ion channel 3 |
|---|---|
| Protein_Sequence | MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQVAERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPAEHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIFTRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQIHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLGSPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLRKDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNYETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQRHSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL |
| Organism_Source | Homo sapiens |
| Functional_Classification | acid-sensing ion channels |
| Cellular_Localization | Plasma membrane |
| Gene_Names | ASIC3 |
| UniProt_ID | Q9UHC3 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | pi-AnmTX Ugr9a-1 |
|---|---|
| Peptide_Sequence | ISIDPPCRFCYHDGCTPESYLTCGVEGCM |
| Peptide_Length | 29 |
| Peptide_SMILES | CC[C@H](C)[C@H](N)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CCSC)C(=O)O)C(C)C)[C@@H](C)O)[C@@H](C)O)[C@@H](C)CC |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3197.65 |
|---|---|
| Aliphatic_Index | 50.34483 |
| Aromaticity | 0.10345 |
| Average_Rotatable_Bonds | 3.27586 |
| Charge_at_pH_7 | -3.21824 |
| Isoelectric_Point | 4.10366 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 48 |
| Number_of_Hydrogen_Bond_Donors | 46 |
| Topological_Polar_Surface_Area | 1212.91000 |
| X_logP_energy | -12.62453 |
Interaction Information
| Affinity | IC50=10 uM |
|---|---|
| Affinity_Assay | two-electrode voltage clamp |
| PDB_ID | 2LZO |
| Type | Ion channel modulator |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Sea anemone peptide with uncommon Beta-hairpin structure inhibits acid-sensing ion channel 3 (ASIC3)and reveals analgesic activity. |
| Release_Year | 2013 |
| PMID | 23801332 |
| DOI | 10.1074/jbc.M113.485516 |