PPIRE14289
Target Protein Information
| Protein_Name | Actin, alpha skeletal muscle |
|---|---|
| Protein_Sequence | MCDEDETTALVCDNGSGLVKAGFAGDDAPRAVFPSIVGRPRHQGVMVGMGQKDSYVGDEAQSKRGILTLKYPIEHGIITNWDDMEKIWHHTFYNELRVAPEEHPTLLTEAPLNPKANREKMTQIMFETFNVPAMYVAIQAVLSLYASGRTTGIVLDSGDGVTHNVPIYEGYALPHAIMRLDLAGRDLTDYLMKILTERGYSFVTTAEREIVRDIKEKLCYVALDFENEMATAASSSSLEKSYELPDGQVITIGNERFRCPETLFQPSFIGMESAGIHETTYNSIMKCDIDIRKDLYANNVMSGGTTMYPGIADRMQKEITALAPSTMKIKIIAPPERKYSVWIGGSILASLSTFQQMWITKQEYDEAGPSIVHRKCF |
| Organism_Source | Oryctolagus cuniculus |
| Functional_Classification | cytoskeletal proteins |
| Cellular_Localization | Cytoplasm |
| Gene_Names | ACTA1 |
| UniProt_ID | P68135 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | RPEL1MAL |
|---|---|
| Peptide_Sequence | SERKNVLQLKLQQRRTREELVSQGIMPPLKS |
| Peptide_Length | 31 |
| Peptide_SMILES | CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CCSC)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Fitc |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3663.30 |
|---|---|
| Aliphatic_Index | 94.19355 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 4.22581 |
| Charge_at_pH_7 | 4.00241 |
| Isoelectric_Point | 11.57928 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 52 |
| Number_of_Hydrogen_Bond_Donors | 57 |
| Topological_Polar_Surface_Area | 1652.67000 |
| X_logP_energy | -17.74262 |
Interaction Information
| Affinity | KD=1 uM |
|---|---|
| Affinity_Assay | Fluorescence Polarization |
| PDB_ID | 2V51 |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL. |
| Release_Year | 2008 |
| PMID | 19008859 |
| DOI | 10.1038/emboj.2008.235 |