PPIRE14295

Target Protein Information
Protein_Name Small conductance calcium-activated potassium channel protein 2
Protein_Sequence MSSCRYNGGVMRPLSNLSSSRRNLHEMDSEAQPLQPPASVVGGGGGASSPSAAAAASSSAPEIVVSKPEHNNSNNLALYGTGGGGSTGGGGGGGGGGGGSGHGSSSGTKSSKKKNQNIGYKLGHRRALFEKRKRLSDYALIFGMFGIVVMVIETELSWGAYDKASLYSLALKCLISLSTIILLGLIIVYHAREIQLFMVDNGADDWRIAMTYERIFFICLEILVCAIHPIPGNYTFTWTARLAFSYAPSTTTADVDIILSIPMFLRLYLIARVMLLHSKLFTDASSRSIGALNKINFNTRFVMKTLMTICPGTVLLVFSISLWIIAAWTVRACERYHDQQDVTSNFLGAMWLISITFLSIGYGDMVPNTYCGKGVCLLTGIMGAGCTALVVAVVARKLELTKAEKHVHNFMMDTQLTKRVKNAAANVLRETWLIYKNTKLVKKIDHAKVRKHQRKFLQAIHQLRSVKMEQRKLNDQANTLVDLAKTQNIMYDMISDLNERSEDFEKRIVTLETKLETLIGSIHALPGLISQTIRQQQRDFIETQMENYDKHVTYNAERSRSSSRRRRSSSTAPPTSSESS
Organism_Source Rattus norvegicus
Functional_Classification small conductance Ca2+-activated potassium channels
Cellular_Localization Plasma membrane
Gene_Names Kcnn2
UniProt_ID P70604
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Tamapin
Peptide_Sequence ATDEYTCQCARDGICRLECSCATTCSCRKNY
Peptide_Length 31
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](C)N)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method Side chain cyclization; C7<->C19; disulfide bond; C9<->C21; disulfide bond; C15<->C25; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification amidation
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3468.90
Aliphatic_Index 34.83871
Aromaticity 0.06452
Average_Rotatable_Bonds 3.64516
Charge_at_pH_7 -0.43340
Isoelectric_Point 6.12866
Number_of_Hydrogen_Bond_Acceptors 57
Number_of_Hydrogen_Bond_Donors 63
Topological_Polar_Surface_Area 1545.26000
X_logP_energy -22.62269
Interaction Information
Affinity IC50=24 pM
Affinity_Assay whole-cell patch-clamp electrophysiology
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title Tamapin, a venom peptide from the Indian red scorpion (Mesobuthus tamulus)that targets small conductance Ca2+-activated K+ channels and afterhyperpolarization currents in central neurons.
Release_Year 2002
PMID 12239213
DOI 10.1074/jbc.M206465200