PPIRE14305
Target Protein Information
| Protein_Name | Apolipoprotein A-I |
|---|---|
| Protein_Sequence | MKAAVLTLAVLFLTGSQARHFWQQDEPPQSPWDRVKDLATVYVDVLKDSGRDYVSQFEGSALGKQLNLKLLDNWDSVTSTFSKLREQLGPVTQEFWDNLEKETEGLRQEMSKDLEEVKAKVQPYLDDFQKKWQEEMELYRQKVEPLRAELQEGARQKLHELQEKLSPLGEEMRDRARAHVDALRTHLAPYSDELRQRLAARLEALKENGGARLAEYHAKATEHLSTLSEKAKPALEDLRQGLLPVLESFKVSFLSALEEYTKKLNTQ |
| Organism_Source | Homo sapiens |
| Functional_Classification | Lipoprotein |
| Cellular_Localization | Extracellular |
| Gene_Names | APOA1 |
| UniProt_ID | P02647 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | Model-1 |
|---|---|
| Peptide_Sequence | YGGFMTSEKSQTPLVTLFKQLLKQLKLLQKL |
| Peptide_Length | 31 |
| Peptide_SMILES | CSCC[C@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)CNC(=O)CNC(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)O)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 3582.35 |
|---|---|
| Aliphatic_Index | 110.00000 |
| Aromaticity | 0.09677 |
| Average_Rotatable_Bonds | 4.06452 |
| Charge_at_pH_7 | 3.99743 |
| Isoelectric_Point | 10.69851 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 49 |
| Number_of_Hydrogen_Bond_Donors | 47 |
| Topological_Polar_Surface_Area | 1388.67000 |
| X_logP_energy | -9.37830 |
Interaction Information
| Affinity | KD=0.71 uM |
|---|---|
| Affinity_Assay | ELISA |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Affinity of nonhomologous amphiphilic peptides toward a monoclonal antibody raised against apolipoprotein A-I. |
| Release_Year | 1986 |
| PMID | 3130624 |
| DOI | 10.1002/prot.340010311 |