PPIRE14421

Target Protein Information
Protein_Name Vasoactive intestinal polypeptide receptor 1
Protein_Sequence MRPPSPLPARWLCVLAGALAWALGPAGGQAARLQEECDYVQMIEVQHKQCLEEAQLENETIGCSKMWDNLTCWPATPRGQVVVLACPLIFKLFSSIQGRNVSRSCTDEGWTHLEPGPYPIACGLDDKAASLDEQQTMFYGSVKTGYTIGYGLSLATLLVATAILSLFRKLHCTRNYIHMHLFISFILRAAAVFIKDLALFDSGESDQCSEGSVGCKAAMVFFQYCVMANFFWLLVEGLYLYTLLAVSFFSERKYFWGYILIGWGVPSTFTMVWTIARIHFEDYGCWDTINSSLWWIIKGPILTSILVNFILFICIIRILLQKLRPPDIRKSDSSPYSRLARSTLLLIPLFGVHYIMFAFFPDNFKPEVKMVFELVVGSFQGFVVAILYCFLNGEVQAELRRKWRRWHLQGVLGWNPKYRHPSGGSNGATCSTQVSMLTRVSPGARRSSSFQAEVSLV
Organism_Source Homo sapiens
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names VIPR1
UniProt_ID P32241
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name TP4200
Peptide_Sequence HADAVFTENYTKLRKQXAAKYLNDLKKAAAXKX
Peptide_Length 33
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)Cc1c[nH]cn1)C(C)C)[C@@H](C)O)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)NCC(=O)N[C@@H](CCCCN)C(=O)NCC(=O)O
Chemical_Modification X17=norleucine; X31=4-aminobutyric acid; X33=Dap-(BMA)2
Cyclization_Method Side chain-side chain cyclization; K21<->D25; amide bond
Linear/Cyclic Cyclic
N-terminal_Modification Acetyl
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3579.08
Aliphatic_Index 65.45455
Aromaticity 0.09091
Average_Rotatable_Bonds 3.75758
Charge_at_pH_7 4.08809
Isoelectric_Point 10.39152
Number_of_Hydrogen_Bond_Acceptors 52
Number_of_Hydrogen_Bond_Donors 54
Topological_Polar_Surface_Area 1563.31000
X_logP_energy -16.52583
Interaction Information
Affinity IC50=8.1 nM
Affinity_Assay muscle relaxivity assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Vasoactive intestinal peptide (VIP)and pituitary adenylate cyclase activating peptide (PACAP)receptor specific peptide analogues for PET imaging of breast cancer: In vitro/in vivo evaluation.
Release_Year 2007
PMID 17727979
DOI 10.1016/j.regpep.2007.06.008