PPIRE14423

Target Protein Information
Protein_Name Genome polyprotein
Protein_Sequence MRCIGISNRDFVEGVSGGSWVDIVLEHGSCVTTMAKNKPTLDFELIKTEAKQPATLRKYCIEAKLTNTTTESRCPTQGEPSLNEEQDKRFVCKHSMVDRGWGNGCGLFGKGGIVTCAMFTCQKNMEGKIVQPENLEYTIVVTPHSGEEHAVGNDTGKHGKEIKITPQSSITEAELTGYGTVTMDCSPRTGLDFNEMVLLQMENKAWLVHRQWFLDLPLPWLPGADTQGSKLDQKETLVTFKNPHAKKQDVVVLGSQEGAMHTALTGATEIQMSSGNLLFTGHLKCRLRMDKLQLKGMSYSMCTGKFKVVEEIAETQHGTIVIRVQYEGDGSPCKIPLEIMDLDNRHVLGRLITVNPIVTEKDSPVNVEAEPPLGDSYIIIGVEPGQLKLNWFKKGSSIGQMFETTMIRAKRMAILGDTAWDFRSLGGVFTSIGKALHQVFGAIYGAAFSGVSWTMKILIGVIITWIGMNSRSTSLSVSLVLVGIVTLYLGVMVQA
Organism_Source Dengue virus type 2 (isolate Malaysia M2)
Functional_Classification viral fusion proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P14338
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DN59
Peptide_Sequence MAILGDTAWDFGSLGGVFTSIGKALHQVFGAIY
Peptide_Length 33
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCCCN)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](N)CCSC)[C@@H](C)CC)[C@@H](C)O)C(C)C)[C@@H](C)O)[C@@H](C)CC)C(C)C)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3443.96
Aliphatic_Index 100.60606
Aromaticity 0.15152
Average_Rotatable_Bonds 3.30303
Charge_at_pH_7 -0.91136
Isoelectric_Point 5.40807
Number_of_Hydrogen_Bond_Acceptors 45
Number_of_Hydrogen_Bond_Donors 45
Topological_Polar_Surface_Area 1283.85000
X_logP_energy -9.42210
Interaction Information
Affinity IC50=10 uM
Affinity_Assay plaque reduction assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Peptide inhibitors of dengue virus and West Nile virus infectivity.
Release_Year 2005
PMID 15927084
DOI 10.1186/1743-422X-2-49