PPIRE14451

Target Protein Information
Protein_Name None
Protein_Sequence MNASHFLASLPPGSTPGENRSRLRDILFNFTNHCQDSVDPTALLITSYGLETVVGVLGNLCLLWVTLRQKDKTNVTNVLIANLAFSDFLMCLLCQPLTVVYTIMDYWIFGEALCKMSAFTQCTSVTVSILSLVLVALERHQLIVNPTGWRPSISQAYLGIVGIWVIATFLSLPFLAHSILDNVFQRNHSKALEFLADKLVCTESWPLDHHRMIYTTFLLLFQYCLPLVFILVCYVRIYRRLRRQGRAFRKGAHSMRGGRVKRVNVVLLAMVVAFAVLWLPLHVFNSLEDWYHEAIPVCHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEVKALVLSCQQRAPREESERLPLSTVHTEVSKGSLRLSGRANPI
Organism_Source Oryctolagus cuniculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names npy4r
UniProt_ID B6VRS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name hPYY(3-36)
Peptide_Sequence IKPEAPGEDASPEELNRYYASLRHYLNLVTRQRY
Peptide_Length 34
Peptide_SMILES CC[C@H](C)[C@H](N)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4050.50
Aliphatic_Index 74.70588
Aromaticity 0.11765
Average_Rotatable_Bonds 3.79412
Charge_at_pH_7 0.09273
Isoelectric_Point 7.52320
Number_of_Hydrogen_Bond_Acceptors 56
Number_of_Hydrogen_Bond_Donors 61
Topological_Polar_Surface_Area 1756.93000
X_logP_energy -16.25042
Interaction Information
Affinity Ki=469 pM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Blockade of pancreatic polypeptide-sensitive neuropeptide Y (NPY)receptors by agonist peptides is prevented by modulators of sodium transport. Implications for receptor signaling and regulation.
Release_Year 2001
PMID 11390018
DOI 10.1016/s0196-9781(01)00414-4