PPIRE14472

Target Protein Information
Protein_Name Interleukin-23 subunit alpha
Protein_Sequence MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPHIQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGHHWETQQIPSLSPSQPWQRLLLRFKILRSLQAFVAVAARVFAHGAATLSP
Organism_Source Homo sapiens
Functional_Classification cytokines
Cellular_Localization Extracellular
Gene_Names IL23A
UniProt_ID Q9NPF7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name PN-05-84
Peptide_Sequence FNMQCLRRMSEAGVDPNLNQEQRWAKIKSIMDDC
Peptide_Length 34
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(=O)O)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CO)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](N)Cc1ccccc1)C(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CS)C(=O)O)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C5<->C34; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4028.62
Aliphatic_Index 60.29412
Aromaticity 0.05882
Average_Rotatable_Bonds 4.08824
Charge_at_pH_7 -0.12168
Isoelectric_Point 6.38885
Number_of_Hydrogen_Bond_Acceptors 58
Number_of_Hydrogen_Bond_Donors 61
Topological_Polar_Surface_Area 1753.86000
X_logP_energy -18.89109
Interaction Information
Affinity IC50=3.3 uM
Affinity_Assay ELISA
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23.
Release_Year 2016
PMID 27881076
DOI 10.1186/s12859-016-1350-9