PPIRE14516

Target Protein Information
Protein_Name None
Protein_Sequence MNASHFLASLPPGSTPGENRSRLRDILFNFTNHCQDSVDPTALLITSYGLETVVGVLGNLCLLWVTLRQKDKTNVTNVLIANLAFSDFLMCLLCQPLTVVYTIMDYWIFGEALCKMSAFTQCTSVTVSILSLVLVALERHQLIVNPTGWRPSISQAYLGIVGIWVIATFLSLPFLAHSILDNVFQRNHSKALEFLADKLVCTESWPLDHHRMIYTTFLLLFQYCLPLVFILVCYVRIYRRLRRQGRAFRKGAHSMRGGRVKRVNVVLLAMVVAFAVLWLPLHVFNSLEDWYHEAIPVCHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEVKALVLSCQQRAPREESERLPLSTVHTEVSKGSLRLSGRANPI
Organism_Source Oryctolagus cuniculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names npy4r
UniProt_ID B6VRS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Human pancreatic polypeptide
Peptide_Sequence APLEPVYPGDNATPEQMAQYAADLRRYINMLTRPRY
Peptide_Length 36
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](C)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](C)N)C(C)C)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4182.74
Aliphatic_Index 65.27778
Aromaticity 0.11111
Average_Rotatable_Bonds 3.52778
Charge_at_pH_7 -0.00099
Isoelectric_Point 6.60225
Number_of_Hydrogen_Bond_Acceptors 57
Number_of_Hydrogen_Bond_Donors 58
Topological_Polar_Surface_Area 1728.41000
X_logP_energy -15.45652
Interaction Information
Affinity Ki=17.9 pM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Blockade of pancreatic polypeptide-sensitive neuropeptide Y (NPY)receptors by agonist peptides is prevented by modulators of sodium transport. Implications for receptor signaling and regulation.
Release_Year 2001
PMID 11390018
DOI 10.1016/s0196-9781(01)00414-4