PPIRE14555

Target Protein Information
Protein_Name None
Protein_Sequence MNASHFLASLPPGSTPGENRSRLRDILFNFTNHCQDSVDPTALLITSYGLETVVGVLGNLCLLWVTLRQKDKTNVTNVLIANLAFSDFLMCLLCQPLTVVYTIMDYWIFGEALCKMSAFTQCTSVTVSILSLVLVALERHQLIVNPTGWRPSISQAYLGIVGIWVIATFLSLPFLAHSILDNVFQRNHSKALEFLADKLVCTESWPLDHHRMIYTTFLLLFQYCLPLVFILVCYVRIYRRLRRQGRAFRKGAHSMRGGRVKRVNVVLLAMVVAFAVLWLPLHVFNSLEDWYHEAIPVCHGNLIFLVCHLLAMASTCVNPFIYGFLNTNFKKEVKALVLSCQQRAPREESERLPLSTVHTEVSKGSLRLSGRANPI
Organism_Source Oryctolagus cuniculus
Functional_Classification G protein-coupled receptor
Cellular_Localization Plasma membrane
Gene_Names npy4r
UniProt_ID B6VRS6
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name (Leu31,Pro34)-hPYY(LP-PYY)
Peptide_Sequence YPIKPEAPGEDASPEELNRYYASLRHYLNLPTRQRY
Peptide_Length 36
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)Cc1ccc(O)cc1)C(=O)N[C@@H](CCCCN)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O)[C@@H](C)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4308.78
Aliphatic_Index 62.50000
Aromaticity 0.13889
Average_Rotatable_Bonds 3.66667
Charge_at_pH_7 0.09188
Isoelectric_Point 7.51629
Number_of_Hydrogen_Bond_Acceptors 59
Number_of_Hydrogen_Bond_Donors 62
Topological_Polar_Surface_Area 1817.78000
X_logP_energy -15.97612
Interaction Information
Affinity Ki=19.7 pM
Affinity_Assay radioligand competition binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Blockade of pancreatic polypeptide-sensitive neuropeptide Y (NPY)receptors by agonist peptides is prevented by modulators of sodium transport. Implications for receptor signaling and regulation.
Release_Year 2001
PMID 11390018
DOI 10.1016/s0196-9781(01)00414-4