PPIRE14612

Target Protein Information
Protein_Name 14-3-3 protein zeta/delta
Protein_Sequence MDKNELVQKAKLAEQAERYDDMAACMKSVTEQGAELSNEERNLLSVAYKNVVGARRSSWRVVSSIEQKTEGAEKKQQMAREYREKIETELRDICNDVLSLLEKFLIPNASQAESKVFYLKMKGDYYRYLAEVAAGDDKKGIVDQSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLSEESYKDSTLIMQLLRDNLTLWTSDTQGDEAEAGEGGEN
Organism_Source Homo sapiens
Functional_Classification adapter proteins
Cellular_Localization Cytoplasm
Gene_Names YWHAZ
UniProt_ID P63104
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Cdc25CpS216
Peptide_Sequence SRSGLYRSPXMPENLNRPRLKQVEKFKDNTIPDKVKKK
Peptide_Length 38
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCSC)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CO)C(C)C)[C@@H](C)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)O)C(C)C
Chemical_Modification X10=phosphoserine
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification FAM
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4456.19
Aliphatic_Index 56.31579
Aromaticity 0.05263
Average_Rotatable_Bonds 4.07895
Charge_at_pH_7 6.99950
Isoelectric_Point 11.16887
Number_of_Hydrogen_Bond_Acceptors 64
Number_of_Hydrogen_Bond_Donors 67
Topological_Polar_Surface_Area 1957.31000
X_logP_energy -21.05152
Interaction Information
Affinity KD=30.4 uM
Affinity_Assay Fluorescence Polarization
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title The Molecular Tweezer CLR01 Stabilizes a Disordered Protein-Protein Interface.
Release_Year 2017
PMID 29039919
DOI 10.1021/jacs.7b07939