PPIRE14652

Target Protein Information
Protein_Name Superoxide dismutase [Cu-Zn]
Protein_Sequence MATKAVCVLKGDGPVQGTIHFEAKGDTVVVTGSITGLTEGDHGFHVHQFGDNTQGCTSAGPHFNPLSKKHGGPKDEERHVGDLGNVTADKNGVAIVDIVDPLISLSGEYSIIGRTMVVHEKPDDLGRGGNEESTKTGNAGSRLACGVIGIAK
Organism_Source Bos taurus
Functional_Classification oxidoreductases
Cellular_Localization Cytoplasm
Gene_Names SOD1
UniProt_ID P00442
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Abeta1-40
Peptide_Sequence DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVG
Peptide_Length 40
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](C)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](C)NC(=O)[C@@H](N)CC(=O)O)C(C)C)C(C)C)C(C)C)C(=O)N[C@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](C(=O)NCC(=O)NCC(=O)N[C@H](C(=O)NCC(=O)O)C(C)C)C(C)C)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4287.78
Aliphatic_Index 82.75000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.57500
Charge_at_pH_7 -2.72407
Isoelectric_Point 5.42863
Number_of_Hydrogen_Bond_Acceptors 59
Number_of_Hydrogen_Bond_Donors 60
Topological_Polar_Surface_Area 1768.87000
X_logP_energy -16.75843
Interaction Information
Affinity KD=12.13 uM
Affinity_Assay fluorimetric analysis
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Interaction of superoxide dismutase with the glycine zipper regions of Beta-amyloid peptides: is there an implication towards Alzheimer's disease and oxidative stress?
Release_Year 2013
PMID 22524677
DOI 10.3109/14756366.2012.680063