PPIRE14692

Target Protein Information
Protein_Name Growth/differentiation factor 8
Protein_Sequence MMQKLQMYVYIYLFMLIAAGPVDLNEGSEREENVEKEGLCNACAWRQNTRYSRIEAIKIQILSKLRLETAPNISKDAIRQLLPRAPPLRELIDQYDVQRDDSSDGSLEDDDYHATTETIITMPTESDFLMQADGKPKCCFFKFSSKIQYNKVVKAQLWIYLRPVKTPTTVFVQILRLIKPMKDGTRYTGIRSLKLDMSPGTGIWQSIDVKTVLQNWLKQPESNLGIEIKALDENGHDLAVTFPGPGEDGLNPFLEVKVTDTPKRSRRDFGLDCDEHSTESRCCRYPLTVDFEAFGWDWIIAPKRYKANYCSGECEFVFLQKYPHTHLVHQANPRGSAGPCCTPTKMSPINMLYFNGKEQIIYGKIPAMVVDRCGCS
Organism_Source Mus musculus
Functional_Classification TGF-beta family
Cellular_Localization Extracellular
Gene_Names Mstn
UniProt_ID O08689
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name mDCN 31-71
Peptide_Sequence DEASGIIPYDPDNPLISMCPYRCQCHLRVVQCSDLGLDKVP
Peptide_Length 41
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](C)NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](N)CC(=O)O)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CCCCN)C(=O)N[C@H](C(=O)N1CCC[C@H]1C(=O)O)C(C)C)C(C)C)C(C)C)[C@@H](C)CC)[C@@H](C)CC
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4562.24
Aliphatic_Index 90.24390
Aromaticity 0.04878
Average_Rotatable_Bonds 3.46341
Charge_at_pH_7 -3.15700
Isoelectric_Point 4.29085
Number_of_Hydrogen_Bond_Acceptors 65
Number_of_Hydrogen_Bond_Donors 63
Topological_Polar_Surface_Area 1816.09000
X_logP_energy -17.49346
Interaction Information
Affinity IC50=3 uM
Affinity_Assay luciferase reporter assay
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Identification of decorin derived peptides with a zinc dependent anti-myostatin activity.
Release_Year 2012
PMID 22854012
DOI 10.1016/j.nmd.2012.07.002