PPIRE14855

Target Protein Information
Protein_Name Large ribosomal subunit protein eL22
Protein_Sequence MAPVKKLVAKGGKKKKQVLKFTLDCTHPVEDGIMDAANFEQFLQERIKVNGKAGNLGGGVVTIERSKSKITVTSEEPFSKRYLKYLTKKYLKKNNLRDWLRVVANSKESYELRYFQINQDEEEEEDED
Organism_Source Rattus norvegicus
Functional_Classification telomere-binding OB-fold protein
Cellular_Localization Nucleus
Gene_Names Rpl22
UniProt_ID P47198
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Pol1CBM
Peptide_Sequence SPLKLQSRKLRYANDVQDLLDDVENSPVVATKRQNV
Peptide_Length 36
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CO)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](C)C(=O)N[C@H](C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@H](C(=O)O)C(C)C)[C@@H](C)O)C(C)C)C(C)C)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 4110.64
Aliphatic_Index 100.00000
Aromaticity 0.02778
Average_Rotatable_Bonds 3.88889
Charge_at_pH_7 0.99980
Isoelectric_Point 9.21815
Number_of_Hydrogen_Bond_Acceptors 59
Number_of_Hydrogen_Bond_Donors 63
Topological_Polar_Surface_Area 1874.19000
X_logP_energy -21.40189
Interaction Information
Affinity KD=3.8 uM
Affinity_Assay Isothermal titration calorimetry
PDB_ID 3OIQ
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structural bases of dimerization of yeast telomere protein Cdc13 and its interaction with the catalytic subunit of DNA polymerase Alpha.
Release_Year 2011
PMID 20877309
DOI 10.1038/cr.2010.138