PPIRE14890
Target Protein Information
| Protein_Name | Tyr recombinase domain-containing protein |
|---|---|
| Protein_Sequence | MAKFIKASSIPSYLSGVVFCLCPLYPEITHIRHDDHIRLVLRGLLRQHGSNINCKQPISFTDLDKLFTTYPHKSYDNQLFLTMLTVGFFGLLRLGELADSNDVRLINRCKTIQHKSLYFTASSAGFILPASKTDRFFAGNKVIVKSNHHHNDPVQAVRLYVNQHDQPFPNLPWLWLTSQGIPPTRSWFLNCFHLHFDTRYRGHSMRAGGATLLAQHGVPFHVIQAIGRWSSETFLIYIRTHPSLLIPAT |
| Organism_Source | Agaricus bisporus var. burnettii |
| Functional_Classification | copper-containing oxidase |
| Cellular_Localization | Lysosome |
| Gene_Names | None |
| UniProt_ID | A0A8H7C4C8 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | RCY |
|---|---|
| Peptide_Sequence | RCY |
| Peptide_Length | 3 |
| Peptide_SMILES | N=C(N)NCCC[C@H](N)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 440.52 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.33333 |
| Average_Rotatable_Bonds | 4.00000 |
| Charge_at_pH_7 | 0.93516 |
| Isoelectric_Point | 8.52721 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 7 |
| Number_of_Hydrogen_Bond_Donors | 9 |
| Topological_Polar_Surface_Area | 203.65000 |
| X_logP_energy | -1.49073 |
Interaction Information
| Affinity | IC50=0.29 uM |
|---|---|
| Affinity_Assay | tyrosinase inhibition assay (L-tyrosine substrate) |
| PDB_ID | 2Y9X |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Serendipitous discovery of short peptides from natural products as tyrosinase inhibitors. |
| Release_Year | 2014 |
| PMID | 25317506 |
| DOI | 10.1021/ci500370x |