PPIRE14952

Target Protein Information
Protein_Name None
Protein_Sequence GLCASQMTDTDRQAMAKSREIEAKNEGAHRVEQEKVKLLLLGAGESGKSTVFKQMKILYGAPLTDEEKRHCTPI
Organism_Source Phytophthora x alni
Functional_Classification serine proteases
Cellular_Localization Cytoplasm
Gene_Names GPA1
UniProt_ID Q2Y0D1
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Ltc1
Peptide_Sequence SMWSGMWRRKLKKLRNALKKKLKGE
Peptide_Length 25
Peptide_SMILES CSCC[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCSC)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 3073.80
Aliphatic_Index 66.40000
Aromaticity 0.08000
Average_Rotatable_Bonds 4.56000
Charge_at_pH_7 8.99768
Isoelectric_Point 12.32561
Number_of_Hydrogen_Bond_Acceptors 42
Number_of_Hydrogen_Bond_Donors 48
Topological_Polar_Surface_Area 1281.99000
X_logP_energy -9.12759
Interaction Information
Affinity IC50=12.68 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Identification of natural antimicrobial agents to treat dengue infection: In vitro analysis of latarcin peptide activity against dengue virus.
Release_Year 2014
PMID 24885331
DOI 10.1186/1471-2180-14-140