PPIRE14962

Target Protein Information
Protein_Name None
Protein_Sequence EYQEFQNRLLIRAREDFGVELAPSLMNLIAGCFYDGILLYAQVLNETIQEGGTREDGLRIV
Organism_Source Mesocricetus auratus
Functional_Classification guanylyl cyclase receptors
Cellular_Localization Plasma membrane
Gene_Names Npr2
UniProt_ID A4UQL7
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name CNP-22
Peptide_Sequence GLSKGCFGLKLDRIGSMSGLGC
Peptide_Length 22
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CC(C)C)NC(=O)CNC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CS)NC(=O)CNC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](CC(C)C)NC(=O)CN)C(=O)NCC(=O)N[C@@H](CO)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N[C@@H](CS)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C6<->C22; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2199.63
Aliphatic_Index 88.63636
Aromaticity 0.04545
Average_Rotatable_Bonds 3.50000
Charge_at_pH_7 1.87389
Isoelectric_Point 8.82155
Number_of_Hydrogen_Bond_Acceptors 33
Number_of_Hydrogen_Bond_Donors 34
Topological_Polar_Surface_Area 886.35000
X_logP_energy -10.57373
Interaction Information
Affinity KD=49.05 nM
Affinity_Assay competitive radioligand binding assay
PDB_ID None
Type Agonist
Structure
Reference Information
Document_Type Research Articles
Title Alteration of lung atrial natriuretic peptide receptors in genetic cardiomyopathy.
Release_Year 1996
PMID 8760130
DOI 10.1152/ajplung.1996.271.1.L38