PPIRE14974

Target Protein Information
Protein_Name Pancreatic triacylglycerol lipase
Protein_Sequence SEVCFPRLGCFSDDAPWAGIVQRPLKILPWSPKDVDTRFLLYTNQNQNNYQELVADPSTITNSNFRMDRKTRFIIHGFIDKGEEDWLSNICKNLFKVESVNCICVDWKGGSRTGYTQASQNIRIVGAEVAYFVEVLKSSLGYSPSNVHVIGHSLGSHAAGEAGRRTNGTIERITGLDPAEPCFQGTPELVRLDPSDAKFVDVIHTDAAPIIPNLGFGMSQTVGHLDFFPNGGKQMPGCQKNILSQIVDIDGIWEGTRDFVACNHLRSYKYYADSILNPDGFAGFPCDSYNVFTANKCFPCPSEGCPQMGHYADRFPGKTNGVSQVFYLNTGDASNFARWRYKVSVTLSGKKVTGHILVSLFGNEGNSRQYEIYKGTLQPDNTHSDEFDSDVEVGDLQKVKFIWYNNNVINPTLPRVGASKITVERNDGKVYDFCSQETVREEVLLTLNPC
Organism_Source Sus scrofa
Functional_Classification lipases
Cellular_Localization Extracellular
Gene_Names PNLIP
UniProt_ID P00591
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name P3
Peptide_Sequence SPFWNINAH
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)CO)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 1085.19
Aliphatic_Index 54.44444
Aromaticity 0.22222
Average_Rotatable_Bonds 3.22222
Charge_at_pH_7 0.08889
Isoelectric_Point 7.55032
Number_of_Hydrogen_Bond_Acceptors 14
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 438.21000
X_logP_energy -3.47550
Interaction Information
Affinity IC50=85.4 uM
Affinity_Assay Enzyme Inhibition Kinetics
PDB_ID 1ETH
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Antioxidant, pancreatic lipase, and Alpha-amylase inhibitory properties of oat bran hydrolyzed proteins and peptides.
Release_Year 2021
PMID 33997997
DOI 10.1111/jfbc.13762