PPIRE14982
Target Protein Information
| Protein_Name | Avidin |
|---|---|
| Protein_Sequence | MVHATSPLLLLLLLSLALVAPGLSARKCSLTGKWTNDLGSNMTIGAVNSRGEFTGTYITAVTATSNEIKESPLHGTQNTINKRTQPTFGFTVNWKFSESTTVFTGQCFIDRNGKEVLKTMWLLRSSVNDIGDDWKATRVGINIFTRLRTQKE |
| Organism_Source | Gallus gallus |
| Functional_Classification | biotin-binding proteins |
| Cellular_Localization | Extracellular |
| Gene_Names | AVD |
| UniProt_ID | P02701 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | CDLASPWCG |
|---|---|
| Peptide_Sequence | CDLASPWCG |
| Peptide_Length | 9 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](CS)C(=O)NCC(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<->C8; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | amide |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 951.08 |
|---|---|
| Aliphatic_Index | 54.44444 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 2.77778 |
| Charge_at_pH_7 | -1.12552 |
| Isoelectric_Point | 3.74996 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 14 |
| Number_of_Hydrogen_Bond_Donors | 14 |
| Topological_Polar_Surface_Area | 360.65000 |
| X_logP_energy | -3.46910 |
Interaction Information
| Affinity | KD=46.2 uM |
|---|---|
| Affinity_Assay | HABA-competitive binding assay |
| PDB_ID | None |
| Type | Affinity ligand |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Highly selective cyclic peptide ligands for NeutrAvidin and avidin identified by phage display. |
| Release_Year | 2006 |
| PMID | 16923020 |
| DOI | 10.1111/j.1747-0285.2006.00401.x |