PPIRE14984

Target Protein Information
Protein_Name Endogenous retrovirus group K member 21 Pro protein/Protein SGT1 homolog
Protein_Sequence WASQVSENRPVCKAIIQGKQFEGLVDTGADVSIIALNQWPKNWPKQKAVTGLVGIGTASEVYQSTEILHCLGPDNQESTVQPMITSIPLNLWGRDLLQQWGAEITMPTPLYSPTSQKIMTKMGYIPGKGLGKNEDGIKVPVEAKINQKREGIGYPF/MAAAAAGTATSQRFFQSFSDALIDEDPQAALEELTKALEQKPDDAQYYCQRAYCHILLGNYCVAVADAKKSLELNPNNSTAMLRKGICEYHEKNYAAALETFTEGQKLDIETGFHRVGQAGLQLLTSSDPPALDSQSAGITGADANFSVWIKRCQEAQNGSESEVWTHQSKIKYDWYQTESQVVITLMIKNVQKNDVNVEFSEKELSALVKLPSGEDYNLKLELLHPIIPEQSTFKVLSTKIEIKLKKPEAVRWEKLEGQGDVPTPKQFVADVKNLYPSSSPYTRNWDKLVGEIKEEEKNEKLEGDAALNRLFQQIYSDGSDEVKRAMNKSFMESGGTVLSTNWSDVGKRKVEINPPDDMEWKKY
Organism_Source Homo sapiens
Functional_Classification G protein-activated inwardly rectifying K? channel
Cellular_Localization Plasma membrane
Gene_Names ERVK-21/SUGT1
UniProt_ID P63119/Q9Y2Z0
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name DS6
Peptide_Sequence KTRMEGNLPAKLRKMNSD
Peptide_Length 18
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](CCSC)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](NC(=O)[C@@H](N)CCCCN)[C@@H](C)O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2089.46
Aliphatic_Index 48.88889
Aromaticity 0.00000
Average_Rotatable_Bonds 4.16667
Charge_at_pH_7 2.99931
Isoelectric_Point 11.05847
Number_of_Hydrogen_Bond_Acceptors 32
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 952.33000
X_logP_energy -11.22726
Interaction Information
Affinity IC50=3.75 uM
Affinity_Assay inside-out patch-clamp electrophysiology
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title A C-terminal peptide of the GIRK1 subunit directly blocks the G protein-activated K+ channel (GIRK)expressed in Xenopus oocytes.
Release_Year 1997
PMID 9409468
DOI 10.1111/j.1469-7793.1997.013bc.x