PPIRE15007

Target Protein Information
Protein_Name Streptavidin
Protein_Sequence MRKIVVAAIAVSLTTVSITASASADPSKDSKAQVSAAEAGITGTWYNQLGSTFIVTAGADGALTGTYESAVGNAESRYVLTGRYDSAPATDGSGTALGWTVAWKNNYRNAHSATTWSGQYVGGAEARINTQWLLTSGTTEANAWKSTLVGHDTFTKVKPSAASIDAAKKAGVNNGNPLDAVQQ
Organism_Source Streptomyces avidinii
Functional_Classification biotin-binding proteins
Cellular_Localization Extracellular
Gene_Names None
UniProt_ID P22629
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name AEGEFCSWAPPKASCGDPAK
Peptide_Sequence AEGEFCSWAPPKASCGDPAK
Peptide_Length 20
Peptide_SMILES C[C@H](N)C(=O)N[C@@H](CCC(=O)O)C(=O)NCC(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CS)C(=O)N[C@@H](CO)C(=O)N[C@@H](Cc1c[nH]c2ccccc12)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)N1CCC[C@H]1C(=O)N[C@@H](C)C(=O)N[C@@H](CCCCN)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2051.28
Aliphatic_Index 20.00000
Aromaticity 0.10000
Average_Rotatable_Bonds 3.00000
Charge_at_pH_7 -1.12256
Isoelectric_Point 4.42631
Number_of_Hydrogen_Bond_Acceptors 30
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 810.04000
X_logP_energy -9.25630
Interaction Information
Affinity IC50=50 uM
Affinity_Assay solid-phase competitive binding assay
PDB_ID None
Type Inhibitor
Structure
Reference Information
Document_Type Research Articles
Title Biotin binders selected from a random peptide library expressed on phage.
Release_Year 1993
PMID 8352728
DOI 10.1042/BJ2930613