PPIRE15016
Target Protein Information
| Protein_Name | Cyanovirin-N |
|---|---|
| Protein_Sequence | LGKFSQTCYNSAIQGSVLTSTCERTNGGYNTSSIDLNSVIENVDGSLKWQPSNFIETCRNTQLAGSSELAAECKTRAQQFVSTKINLDDHIANIDGTLKYE |
| Organism_Source | Nostoc ellipsosporum |
| Functional_Classification | lectins |
| Cellular_Localization | Extracellular |
| Gene_Names | None |
| UniProt_ID | P81180 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | P2 |
|---|---|
| Peptide_Sequence | CDQXETDSSGDG |
| Peptide_Length | 12 |
| Peptide_SMILES | C[C@@H](O)[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@@H](N)CS)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)NCC(=O)O |
| Chemical_Modification | X4=Mana(1 2)Mana |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1170.08 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.25000 |
| Charge_at_pH_7 | -4.06088 |
| Isoelectric_Point | 3.26047 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 22 |
| Number_of_Hydrogen_Bond_Donors | 22 |
| Topological_Polar_Surface_Area | 636.40000 |
| X_logP_energy | -12.52510 |
Interaction Information
| Affinity | KD=10 uM |
|---|---|
| Affinity_Assay | Surface plasmon resonance |
| PDB_ID | 3EZM |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Mannosylated hemagglutinin peptides bind cyanovirin-N independent of disulfide-bonds in complementary binding sites. |
| Release_Year | 2020 |
| PMID | 35495330 |
| DOI | 10.1039/d0ra01128b |