PPIRE15051
Target Protein Information
| Protein_Name | None |
|---|---|
| Protein_Sequence | YLEQGQNLRMTGHLHHLEPKRVKIIVEEVRLALTEGKLLKMLGSQEPRYLIQLPYVWIEKYPWQPGRSRVPGTSLTSEEKKLIEKKLPDNLPDAKLVSSFEFMELIDFLHKRSQEELPSNHQMPLSEAFAEHIKRRLLYSGTVTRIDSP |
| Organism_Source | Aphanizomenon flos-aquae var. klebahnii |
| Functional_Classification | transcriptional regulator |
| Cellular_Localization | Cytoplasm |
| Gene_Names | hetR |
| UniProt_ID | Q8KXC6 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | PatS-6nD |
|---|---|
| Peptide_Sequence | DRGSGR |
| Peptide_Length | 6 |
| Peptide_SMILES | N=C(N)NCCC[C@H](NC(=O)CNC(=O)[C@H](CO)NC(=O)CNC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H](N)CC(=O)O)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | None |
| Linear/Cyclic | Linear |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 646.66 |
|---|---|
| Aliphatic_Index | 0.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 3.66667 |
| Charge_at_pH_7 | 0.99842 |
| Isoelectric_Point | 10.39777 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 11 |
| Number_of_Hydrogen_Bond_Donors | 15 |
| Topological_Polar_Surface_Area | 390.15000 |
| X_logP_energy | -6.92136 |
Interaction Information
| Affinity | KD=25.7 nM |
|---|---|
| Affinity_Assay | Isothermal titration calorimetry |
| PDB_ID | 4YNL |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Differential binding between PatS C-terminal peptide fragments and HetR from Anabaena sp. PCC 7120. |
| Release_Year | 2012 |
| PMID | 22397695 |
| DOI | 10.1021/bi300228n |