PPIRE15107

Target Protein Information
Protein_Name High affinity immunoglobulin epsilon receptor subunit alpha
Protein_Sequence MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
Organism_Source Homo sapiens
Functional_Classification immunoglobulin receptors
Cellular_Localization plasma membrane
Gene_Names FCER1A
UniProt_ID P12319
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name IGE06
Peptide_Sequence NLPRCTEGPWGWVCMAAD
Peptide_Length 18
Peptide_SMILES CSCC[C@H](NC(=O)[C@H](CS)NC(=O)[C@@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)CNC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@@H]1CCCN1C(=O)CNC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@H](CS)NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CC(C)C)NC(=O)[C@@H](N)CC(N)=O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](C)C(=O)N[C@@H](C)C(=O)N[C@@H](CC(=O)O)C(=O)O
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C5<->C14; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2006.30
Aliphatic_Index 48.88889
Aromaticity 0.11111
Average_Rotatable_Bonds 3.16667
Charge_at_pH_7 -1.12375
Isoelectric_Point 4.18434
Number_of_Hydrogen_Bond_Acceptors 27
Number_of_Hydrogen_Bond_Donors 28
Topological_Polar_Surface_Area 771.84000
X_logP_energy -6.42333
Interaction Information
Affinity IC50=3.6 uM
Affinity_Assay ELISA
PDB_ID 1JBF
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Convergent recognition of the IgE binding site on the high-affinity IgE receptor.
Release_Year 2004
PMID 15242605
DOI 10.1016/j.str.2004.04.015