PPIRE15108

Target Protein Information
Protein_Name High affinity immunoglobulin epsilon receptor subunit alpha
Protein_Sequence MAPAMESPTLLCVALLFFAPDGVLAVPQKPKVSLNPPWNRIFKGENVTLTCNGNNFFEVSSTKWFHNGSLSEETNSSLNIVNAKFEDSGEYKCQHQQVNESEPVYLEVFSDWLLLQASAEVVMEGQPLFLRCHGWRNWDVYKVIYYKDGEALKYWYENHNISITNATVEDSGTYYCTGKVWQLDYESEPLNITVIKAPREKYWLQFFIPLLVVILFAVDTGLFISTQQQVTFLLKIKRTRKGFRLLNPHPKPNPKNN
Organism_Source Homo sapiens
Functional_Classification immunoglobulin receptors
Cellular_Localization plasma membrane
Gene_Names FCER1A
UniProt_ID P12319
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name e109
Peptide_Sequence VQCPHFCYELDYELCPDVCYV
Peptide_Length 21
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CS)NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CS)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CS)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CC(=O)O)C(=O)N[C@H](C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1ccc(O)cc1)C(=O)N[C@H](C(=O)O)C(C)C)C(C)C
Chemical_Modification None
Cyclization_Method Side chain-side chain cyclization; C3<->C17; disulfide bond
Linear/Cyclic Cyclic
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2538.91
Aliphatic_Index 78.57143
Aromaticity 0.19048
Average_Rotatable_Bonds 3.47619
Charge_at_pH_7 -4.15711
Isoelectric_Point 3.73724
Number_of_Hydrogen_Bond_Acceptors 35
Number_of_Hydrogen_Bond_Donors 33
Topological_Polar_Surface_Area 909.40000
X_logP_energy -4.11600
Interaction Information
Affinity IC50=1.4 uM
Affinity_Assay ELISA
PDB_ID None
Type antagonist
Structure
Reference Information
Document_Type Research Articles
Title Convergent recognition of the IgE binding site on the high-affinity IgE receptor.
Release_Year 2004
PMID 15242605
DOI 10.1016/j.str.2004.04.015