PPIRE15110

Target Protein Information
Protein_Name Cholera enterotoxin subunit A
Protein_Sequence MVKIIFVFFIFLSSFSYANDDKLYRADSRPPDEIKQSGGLMPRGQSEYFDRGTQMNINLYDHARGTQTGFVRHDDGYVSTSISLRSAHLVGQTILSGHSTYYIYVIATAPNMFNVNDVLGAYSPHPDEQEVSALGGIPYSQIYGWYRVHFGVLDEQLHRNRGYRDRYYSNLDIAPAADGYGLAGFPPEHRAWREEPWIHHAPPGCGNAPRSSMSNTCDEKTQSLGVKFLDEYQSKVKRQIFSGYQSDIDTHNRIKDEL
Organism_Source Vibrio cholerae serotype O1 (strain ATCC 39315 / El Tor Inaba N16961)
Functional_Classification AB5 toxins
Cellular_Localization extracellular
Gene_Names ctxA
UniProt_ID P01555
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name Minimal epitope peptide
Peptide_Sequence VPGSQHIDS
Peptide_Length 9
Peptide_SMILES CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H]1CCCN1C(=O)[C@@H](N)C(C)C)C(=O)N[C@@H](CC(=O)O)C(=O)N[C@@H](CO)C(=O)O
Chemical_Modification None
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification Free
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 938.99
Aliphatic_Index 75.55556
Aromaticity 0.00000
Average_Rotatable_Bonds 3.11111
Charge_at_pH_7 -0.91066
Isoelectric_Point 5.29226
Number_of_Hydrogen_Bond_Acceptors 15
Number_of_Hydrogen_Bond_Donors 14
Topological_Polar_Surface_Area 436.86000
X_logP_energy -6.19300
Interaction Information
Affinity KD=10 uM
Affinity_Assay ELISA
PDB_ID None
Type Affinity ligand
Structure
Reference Information
Document_Type Research Articles
Title Structure of an anti-cholera toxin antibody Fab in complex with an epitope-derived D-peptide: a case of polyspecific recognition.
Release_Year 2007
PMID 17712773
DOI 10.1002/jmr.838