PPIRE15118

Target Protein Information
Protein_Name Potassium voltage-gated channel subfamily A member 2
Protein_Sequence MTVATGDPSDEAAAHPGNPAEYDPDADHECCERVVINISGLRFETQLKTLSQFPDTLLGDPKKRMRYFDPLRNEYFFDRSRTSFDAILYFYQSGGRLRRPANVTLDIFSEEIRFYELGDEAIELFREDEGFVKEEERPLPDNEFQRQVWLLFEYPESSGPARIIAIISVMVILISIVSFCLETLPIFRNDDDEPHSVFDTNTNTTIYFTSTYFTDPFFILETLCIIWFSFEFLVRLFACPSKSGFFGNVMNIIDVVAIIPYFITLATELAEKPEDGQAGQQAMSLAILRVIRLVRVFRIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAEADEPESQFESIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYHRETEGEEQAQCLGPVTKEDSNEELKKSRSGSTISKSDYMEIQEGVNNTIEDIPEENLKTQANCTTLANTNYVNITKMLTDV
Organism_Source Oncorhynchus mykiss
Functional_Classification TSha1 K+ channel (closed)
Cellular_Localization plasma membrane
Gene_Names kcna2
UniProt_ID Q9I830
Protein-Protein Interaction Networks
Peptide Basic Information
Peptide_Name alphaM-conotoxin RIIIK
Peptide_Sequence LXSCCSLNLRLCXVXACKRNXCCT
Peptide_Length 24
Peptide_SMILES CC(C)C[C@H](NC(=O)[C@H](CCCNC(=N)N)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC(N)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CO)NC(=O)[C@H](CS)NC(=O)[C@H](CS)NC(=O)[C@H](CO)NC(=O)CNC(=O)[C@@H](N)CC(C)C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N[C@H](C(=O)NCC(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CC(N)=O)C(=O)NCC(=O)N[C@@H](CS)C(=O)N[C@@H](CS)C(=O)N[C@H](C(=O)O)[C@@H](C)O)C(C)C
Chemical_Modification X2=4-trans-hydroxyproline; X13=4-trans-hydroxyproline; X15=4-trans-hydroxyproline; X21=4-trans-hydroxyproline
Cyclization_Method None
Linear/Cyclic Linear
N-terminal_Modification Free
C-terminal_Modification amide
Amino_Acid_Distribution
Peptide Physicochemical
Molecular_Weight 2431.92
Aliphatic_Index 81.25000
Aromaticity 0.00000
Average_Rotatable_Bonds 3.37500
Charge_at_pH_7 2.62583
Isoelectric_Point 8.38810
Number_of_Hydrogen_Bond_Acceptors 39
Number_of_Hydrogen_Bond_Donors 43
Topological_Polar_Surface_Area 1029.31000
X_logP_energy -15.71486
Interaction Information
Affinity IC50=60 nM
Affinity_Assay two-electrode voltage-clamp electrophysiology
PDB_ID None
Type Ion channel modulator
Structure
Reference Information
Document_Type Research Articles
Title A novel conus peptide ligand for K+ channels.
Release_Year 2003
PMID 12399472
DOI 10.1074/jbc.M205953200