PPIRE15194
Target Protein Information
| Protein_Name | Cell division protein FtsA |
|---|---|
| Protein_Sequence | MASVQSGKMIVGLDIGTSKVVALVGEVTADGQLEVVGIGTHPSRGLKKGVVVNIESTVQSIQRAIDEAQQMAGCRIHSAFVGIAGNHIRSLNSHGIVAIRDREVNPADIERVLDAAQAVAIPADQRVLHTLAQDYVIDNQEGVREPLGMSGVRLEAKVHVVTCAVNASQNIEKCVRRCGLEVDDIILEQLASAYSVLTEDEKELGVCLVDIGGGTTDIAIFTEGAIRHTAVIPIAGDQVTNDIAMALRTPTQYAEEIKIRYACALAKLAGAGETIKVPSVGDRPPRELSRQALAEVVEPRYDELFTLVQAELRRSGYEDLIPAGIVLTGGTSKMEGAVELAEEIFHMPVRLGVPYSVKGLTDVVRNPIYSTGVGLLMYGLQKQSDGMSMSVSGSSYSSDEPKAPVLERLKRWVQGNF |
| Organism_Source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
| Functional_Classification | ATPases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | ftsA |
| UniProt_ID | P47203 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FtsAp1 |
|---|---|
| Peptide_Sequence | CLAPSPPSKC |
| Peptide_Length | 10 |
| Peptide_SMILES | CC(C)C[C@H](NC(=O)[C@@H](N)CS)C(=O)N[C@@H](C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<-->C9; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 1002.21 |
|---|---|
| Aliphatic_Index | 49.00000 |
| Aromaticity | 0.00000 |
| Average_Rotatable_Bonds | 2.60000 |
| Charge_at_pH_7 | 0.87374 |
| Isoelectric_Point | 8.22969 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 13 |
| Topological_Polar_Surface_Area | 365.33000 |
| X_logP_energy | -4.68070 |
Interaction Information
| Affinity | IC50=22 mM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Peptide inhibitors of the essential cell division protein FtsA |
| Release_Year | 2005 |
| PMID | 15790573 |
| DOI | 10.1093/protein/gzi008 |