PPIRE15198
Target Protein Information
| Protein_Name | Cell division protein FtsA |
|---|---|
| Protein_Sequence | MASVQSGKMIVGLDIGTSKVVALVGEVTADGQLEVVGIGTHPSRGLKKGVVVNIESTVQSIQRAIDEAQQMAGCRIHSAFVGIAGNHIRSLNSHGIVAIRDREVNPADIERVLDAAQAVAIPADQRVLHTLAQDYVIDNQEGVREPLGMSGVRLEAKVHVVTCAVNASQNIEKCVRRCGLEVDDIILEQLASAYSVLTEDEKELGVCLVDIGGGTTDIAIFTEGAIRHTAVIPIAGDQVTNDIAMALRTPTQYAEEIKIRYACALAKLAGAGETIKVPSVGDRPPRELSRQALAEVVEPRYDELFTLVQAELRRSGYEDLIPAGIVLTGGTSKMEGAVELAEEIFHMPVRLGVPYSVKGLTDVVRNPIYSTGVGLLMYGLQKQSDGMSMSVSGSSYSSDEPKAPVLERLKRWVQGNF |
| Organism_Source | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) |
| Functional_Classification | ATPases |
| Cellular_Localization | Cytoplasm |
| Gene_Names | ftsA |
| UniProt_ID | P47203 |
| Protein-Protein Interaction Networks | |
Peptide Basic Information
| Peptide_Name | FtsAp6 |
|---|---|
| Peptide_Sequence | CTGHWASEC |
| Peptide_Length | 9 |
| Peptide_SMILES | C[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](Cc1c[nH]cn1)NC(=O)CNC(=O)[C@@H](NC(=O)[C@@H](N)CS)[C@@H](C)O)C(=O)N[C@@H](CO)C(=O)N[C@@H](CCC(=O)O)C(=O)N[C@@H](CS)C(=O)O |
| Chemical_Modification | None |
| Cyclization_Method | Side chain-side chain cyclization; C1<-->C9; disulfide bond |
| Linear/Cyclic | Cyclic |
| N-terminal_Modification | Free |
| C-terminal_Modification | Free |
| Amino_Acid_Distribution | |
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Peptide Physicochemical
| Molecular_Weight | 993.08 |
|---|---|
| Aliphatic_Index | 11.11111 |
| Aromaticity | 0.11111 |
| Average_Rotatable_Bonds | 3.11111 |
| Charge_at_pH_7 | -1.03328 |
| Isoelectric_Point | 5.35867 |
|---|---|
| Number_of_Hydrogen_Bond_Acceptors | 16 |
| Number_of_Hydrogen_Bond_Donors | 17 |
| Topological_Polar_Surface_Area | 418.35000 |
| X_logP_energy | -5.28470 |
Interaction Information
| Affinity | IC50=35 mM |
|---|---|
| Affinity_Assay | Enzyme Inhibition Kinetics |
| PDB_ID | None |
| Type | Inhibitor |
| Structure | |
Reference Information
| Document_Type | Research Articles |
|---|---|
| Title | Peptide inhibitors of the essential cell division protein FtsA |
| Release_Year | 2005 |
| PMID | 15790573 |
| DOI | 10.1093/protein/gzi008 |